The protein corona from nanomedicine to environmental science

M Mahmoudi, MP Landry, A Moore… - Nature Reviews Materials, 2023 - nature.com
The protein corona spontaneously develops and evolves on the surface of nanoscale
materials when they are exposed to biological environments, altering their physiochemical …

Nanoparticle protein corona: from structure and function to therapeutic targeting

G Bashiri, MS Padilla, KL Swingle, SJ Shepherd… - Lab on a Chip, 2023 - pubs.rsc.org
Nanoparticle (NP)-based therapeutics have ushered in a new era in translational medicine.
However, despite the clinical success of NP technology, it is not well-understood how NPs …

Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery

W Kim, NK Ly, Y He, Y Li, Z Yuan, Y Yeo - Advanced drug delivery reviews, 2023 - Elsevier
For systemically delivered nanoparticles to reach target tissues, they must first circulate long
enough to reach the target and extravasate there. A challenge is that the particles end up …

The role of protein corona on nanodrugs for organ-targeting and its prospects of application

S Wang, J Zhang, H Zhou, YC Lu, X Jin, L Luo… - Journal of Controlled …, 2023 - Elsevier
Nowadays, nanodrugs become a hotspot in the high-end medical field. They have the ability
to deliver drugs to reach their destination more effectively due to their unique properties and …

Protein corona formation on lipid nanoparticles negatively affects the NLRP3 inflammasome activation

M Debnath, J Forster III, A Ramesh… - Bioconjugate …, 2023 - ACS Publications
The interaction between lipid nanoparticles (LNPs) and serum proteins, giving rise to a
unique identification in the form of the protein corona, has been shown to be associated with …

The Janus of Protein Corona on nanoparticles for tumor targeting, immunotherapy and diagnosis

X Wang, W Zhang - Journal of Controlled Release, 2022 - Elsevier
The therapeutics based on nanoparticles (NPs) are considered as the promising strategy for
tumor detection and treatment. However, one of the most challenges is the adsorption of …

Nanoparticle-protein corona complex: understanding multiple interactions between environmental factors, corona formation, and biological activity

A Tomak, S Cesmeli, BD Hanoglu, D Winkler… - …, 2021 - Taylor & Francis
The surfaces of pristine nanoparticles become rapidly coated by proteins in biological fluids,
forming the so-called protein corona. The corona modifies key physicochemical …

Biological features of nanoparticles: protein corona formation and interaction with the immune system

S Panico, S Capolla, S Bozzer, G Toffoli, M Dal Bo… - Pharmaceutics, 2022 - mdpi.com
Nanoparticles (NPs) are versatile candidates for nanomedical applications due to their
unique physicochemical properties. However, their clinical applicability is hindered by their …

Nanoparticles in medicine: current status in cancer treatment

K Pavelić, SK Pavelić, A Bulog, A Agaj… - International journal of …, 2023 - mdpi.com
Cancer is still a leading cause of deaths worldwide, especially due to those cases
diagnosed at late stages with metastases that are still considered untreatable and are …

[HTML][HTML] Protonated-chitosan sponge with procoagulation activity for hemostasis in coagulopathy

Z Huang, D Zhang, L Tong, F Gao, S Zhang, X Wang… - Bioactive Materials, 2024 - Elsevier
Hemostatic materials are essential for managing acute bleeding in medical settings.
Chitosan (CS) shows promise in hemostasis but its underlying mechanism remains …