ANGPTL8 (betatrophin) role in diabetes and metabolic diseases

M Abu‐Farha, J Abubaker… - … metabolism research and …, 2017 - Wiley Online Library
Diabetes is a major disease worldwide that is reaching epidemic levels. Its increased
prevalence as well as its association with a high number of complications such as …

ANGPTL8 in metabolic homeostasis: more friend than foe?

C Guo, C Wang, X Deng, J He, L Yang… - Open …, 2021 - royalsocietypublishing.org
ANGPTL8 is an important cytokine, which is significantly increased in type 2 diabetes
mellitus (T2DM), obesity and metabolic syndrome. Many studies have shown that ANGPTL8 …

[HTML][HTML] Comparison of anthropometric indices for predicting the risk of metabolic syndrome and its components in Chinese adults: a prospective, longitudinal study

H Wang, A Liu, T Zhao, X Gong, T Pang, Y Zhou… - BMJ open, 2017 - bmjopen.bmj.com
Objectives Our study aimed to distinguish the ability of anthropometric indices to assess the
risk of metabolic syndrome (MetS). Design Prospective cohort study. Setting Shenyang …

[HTML][HTML] The effects of serum ANGPTL8/betatrophin on the risk of developing the metabolic syndrome–a prospective study

H Wang, Y Lai, C Han, A Liu, C Fan, H Wang… - Scientific reports, 2016 - nature.com
ANGPTL8/betatrophin is a recently discovered hormone, which mainly synthesized and
secreted by liver and adipose tissue, playing a critical role in pancreatic beta cell …

Angiopoietin-like protein 8 (betatrophin) inhibits hepatic gluconeogenesis through PI3K/Akt signaling pathway in diabetic mice

Z Zhao, X Deng, J Jia, L Zhao, C Wang, Z Cai, C Guo… - Metabolism, 2022 - Elsevier
Background & aims Angiopoietin-like protein 8 (ANGPTL8) is a 198 amino-acid long, novel
secreted protein that is mainly expressed in the liver and brown adipose tissues. At present …

[HTML][HTML] Betatrophin and insulin resistance

Q Guo, S Cao, X Wang - Metabolites, 2022 - mdpi.com
Betatrophin (angiopoietin-like protein 8 (ANGPTL8)) is a hormone that was recently
discovered in the human liver. Multiple homologous sequences have been detected in …

Iodoacetic Acid Disrupting the Thyroid Endocrine System in Vitro and in Vivo

Y Xia, Y Mo, Q Yang, Y Yu, M Jiang, S Wei… - … science & technology, 2018 - ACS Publications
Exposure to drinking water disinfection byproducts (DBPs) is potentially associated with
adverse developmental effects. Iodoacetic acid (IAA), an unregulated DBP, has been shown …

ANGPTL8 roles in proliferation, metabolic diseases, hypothyroidism, polycystic ovary syndrome, and signaling pathways

M Navaeian, S Asadian, H Ahmadpour Yazdi… - Molecular biology …, 2021 - Springer
A new and atypical member of the ANGPTL family is angiopoietin-like protein 8 (ANGPTL8).
This newly discovered hormone is a drug target that can be used to treat diabetes and …

Thyroid function in patients with type 2 diabetes mellitus and diabetic nephropathy: a single center study

W Zhao, X Li, X Liu, L Lu, Z Gao - Journal of Thyroid Research, 2018 - Wiley Online Library
Background. Diabetes mellitus is a common metabolic disease and the prevalence is
increasing rapidly. Thyroid disorders including subclinical hypothyroidism (SCH) and low …

Circulating Angptl3 and Angptl8 are increased in patients with hypothyroidism

L Yang, R Yin, Z Wang, X Wang… - BioMed research …, 2019 - Wiley Online Library
Purpose. Angiopoietin‐like proteins (Angptls) play critical roles in biological processes,
primarily in lipid metabolism. The functional state of the thyroid has a profound influence on …