Systemic autoimmune diseases (SAIDs), such as systemic lupus erythematosus (SLE),
systemic sclerosis (SSc) and rheumatoid arthritis (RA), are fully related to the unregulated …

Uveal melanoma (UM) is the most common cancer of the eye. The loss of chromosome 3
(M3) is associated with a high risk of metastases. M3 tumors are more infiltrated by T …

Background Colon adenocarcinoma (COAD) is a common digestive system malignancy with
high mortality and poor prognosis. Accumulating evidence indicates that choline metabolism …

End-stage liver disease (ESLD) from acute liver failure to compensated advanced chronic
liver disease and decompensated cirrhosis at different stages (chronic decompensation …

T cell exhaustion impairs tumor immunity and contributes to resistance against immune
checkpoint inhibitors. The nuclear receptor subfamily 4 group A (NR4a) family of nuclear …

Recent studies have indicated a key role of the impaired suppressive capacity of regulatory
T cells (Tregs) in psoriasis (PsO) pathogenesis. However, the genetic background of Treg …

Graft-versus-host disease (GVHD) is a T cell-mediated inflammatory disorder that arises
from allogeneic haematopoietic stem cell transplantation and is often fatal. The P2X7 …

The regulatory T cell master transcription factor, Forkhead box P3 (Foxp3), has been
detected in cancer cells; however, its role in breast tumor pathogenesis remains …

Recent studies have indicated a key role of the impaired suppressive capacity of regulatory
T cells (Tregs) in psoriasis (PsO) pathogenesis. However, the genetic background of Treg …

Despite the large public health toll of smoking, genetic studies of smoking cessation have
been limited with few discoveries of risk or protective loci. We investigated common and rare …