Neuroinflammation is a complex process involving both the peripheral circulation and the
Central Nervous System (CNS) and is considered to underlie many CNS disorders including …

Cholinergic signaling is crucial in cognitive processes, and degenerating cholinergic
projections are a pathological hallmark in dementia. Use of cholinesterase inhibitors is …

Stroke is a common disease in clinical practice, which seriously endangers people's
physical and mental health. The neurovascular unit (NVU) plays a key role in the occurrence …

Electrical stimulation has been extensively applied in post-stroke motor restoration, but its
treatment mechanisms are not fully understood. Stimulation of neuromotor control system at …

Although the memory-improving effect of crocin has been suggested by previous evidences,
the association between this effect and hippocampal acetylcholine (Ach) level and apoptosis …

Nicotinic acetylcholine α7 receptors (α7 nAChRs) have a well-known modulator effect in
neuroinflammation. Yet, the therapeutical effect of α7 nAChRs activation after stroke has …

Ischemic stroke is a major cause of mortality and neurological morbidity worldwide. The
underlying pathophysiology of ischemic stroke is highly complicated and correlates with …

Stroke remains a major unmet clinical need that warrants novel therapies. Following an
ischemic insult, the cerebral vasculature secretes inflammatory molecules, creating the …

Metabolic adaption drives microglial inflammatory responses, and lactate shapes
immunological and inflammatory states. However, whether lactate was involved in the …

Purinergic signaling encompasses the cycle of adenosine 5′ triphosphate (ATP) release
and its metabolism into nucleotide and nucleoside derivatives, the direct release of …