Brownian dynamics (BD) is a technique for carrying out computer simulations of physical
systems that are driven by thermal fluctuations. Biological systems at the macromolecular …

Brownian dynamics (BD) is a computational method to simulate molecular diffusion
processes. Although the BD method has been developed over several decades and is well …

When the J-domain of the heat shock protein DnaJB1 is fused to the catalytic (C) subunit of
cAMP-dependent protein kinase (PKA), replacing exon 1, this fusion protein, JC subunit …

Protein kinase A (PKA) holoenzyme, comprised of a cAMP-binding regulatory (R)-subunit
dimer and 2 catalytic (C)-subunits, is the master switch for cAMP-mediated signaling. Of the …

Fibrolamellar hepatocellular carcinoma (FLHCC) is driven by J-PKAcα, a kinase fusion
chimera of the J domain of DnaJB1 with PKAcα, the catalytic subunit of protein kinase A …

Vibrational sum frequency generation (VSFG) spectroscopy and surface pressure
measurements are used to investigate the adsorption of a globular protein, bovine serum …

Protein kinases are dynamic molecular switches that sample multiple conformational states.
The regulatory subunit of PKA harbors two cAMP-binding domains [cyclic nucleotide-binding …

The fields of allostery and amyloid-related pathologies, such as Parkinson's disease (PD),
have been extensively explored individually, but less is known about how amyloids control …

In cAMP-Protein Kinase A (PKA) signaling, A-kinase anchoring protein scaffolds assemble
PKA in close proximity to phosphodiesterases (PDE), kinase-substrates to form signaling …

Protein kinase A (PKA) is a ubiquitous cAMP-dependent enzyme in mammalian tissues. The
inactive PKA holoenzyme disassociates into a homodimer of regulatory (R) subunits and two …