The release of the inherent ring strain of cyclobutane and cyclopropane derivatives allows a
rapid build-up of molecular complexity. This review highlights the state-of-the-art of the ring …

Biocatalysis is becoming an increasingly impactful method in contemporary synthetic
chemistry for target molecule synthesis. The selectivity imparted by enzymes has been …

Natural products are the result of Nature's exploration of biologically relevant chemical
space through evolution and an invaluable source of bioactive small molecules for chemical …

An approach to the generation of ultra-large chemical libraries of readily accessible ("
REAL") compounds is described. The strategy is based on the use of two-or three-step three …

Current medicinal chemistry relies heavily on the quality of building blocks, ie reagents used
to introduce chemical diversity into the target molecules. The last decade witnessed an …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 4
million humans globally, but there is no bona fide Food and Drug Administration–approved …

The discovery of new molecules and materials helps expand the horizons of novel and
innovative real-life applications. In pursuit of finding molecules with desired properties …

The ability to efficiently synthesize desired compounds can be a limiting factor for chemical
space exploration in drug discovery. This ability is conditioned not only by the existence of …

This Review describes the increasing demand for organic synthesis to facilitate fragment-
based drug discovery (FBDD), focusing on polar, unprotected fragments. In FBDD, X-ray …

Directed C–H functionalization is a powerful means to functionalize otherwise unreactive C–
H bonds, for which aminoquinoline amides provide a powerful and frequently used directing …