[HTML][HTML] Purinergic signalling: therapeutic developments
G Burnstock - Frontiers in pharmacology, 2017 - frontiersin.org
Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …
proposed in 1972. However, this concept was not well accepted until the early 1990's when …
Medicinal chemistry of adenosine, P2Y and P2X receptors
KA Jacobson, CE Müller - Neuropharmacology, 2016 - Elsevier
Pharmacological tool compounds are now available to define action at the adenosine (ARs),
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …
Animal models of pain: diversity and benefits
C Abboud, A Duveau, R Bouali-Benazzouz… - Journal of neuroscience …, 2021 - Elsevier
Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …
Purinergic signalling in brain ischemia
Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …
After ischemia a primary damage due to the early massive increase of extracellular …
Purinergic mechanisms and pain
G Burnstock - Advances in Pharmacology, 2016 - Elsevier
There is a brief introductory summary of purinergic signaling involving ATP storage, release,
and ectoenzymatic breakdown, and the current classification of receptor subtypes for …
and ectoenzymatic breakdown, and the current classification of receptor subtypes for …
Enteric glial cells: a new frontier in neurogastroenterology and clinical target for inflammatory bowel diseases
F Ochoa-Cortes, F Turco, A Linan-Rico… - Inflammatory bowel …, 2016 - academic.oup.com
The word “glia” is derived from the Greek word “γλoια,” glue of the enteric nervous system,
and for many years, enteric glial cells (EGCs) were believed to provide mainly structural …
and for many years, enteric glial cells (EGCs) were believed to provide mainly structural …
P2X ion channel receptors and inflammation
G Burnstock - Purinergic signalling, 2016 - Springer
Neuroinflammation limits tissue damage in response to pathogens or injury and promotes
repair. There are two stages of inflammation, initiation and resolution. P2X receptors are …
repair. There are two stages of inflammation, initiation and resolution. P2X receptors are …
[HTML][HTML] Ectonucleotidases in acute and chronic inflammation
AL Giuliani, AC Sarti, F Di Virgilio - Frontiers in Pharmacology, 2021 - frontiersin.org
Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that
hydrolyse extracellular purine and pyrimidine nucleotides, eg, ATP, UTP, ADP, UDP, AMP …
hydrolyse extracellular purine and pyrimidine nucleotides, eg, ATP, UTP, ADP, UDP, AMP …
The therapeutic potential of purinergic signalling
G Burnstock - Biochemical pharmacology, 2018 - Elsevier
This review is focused on the pathophysiology and therapeutic potential of purinergic
signalling. A wide range of diseases are considered, including those of the central nervous …
signalling. A wide range of diseases are considered, including those of the central nervous …
[HTML][HTML] Mechanosensory signaling in enterochromaffin cells and 5-HT release: potential implications for gut inflammation
Enterochromaffin (EC) cells synthesize 95% of the body 5-HT and release 5-HT in response
to mechanical or chemical stimulation. EC cell 5-HT has physiological effects on gut motility …
to mechanical or chemical stimulation. EC cell 5-HT has physiological effects on gut motility …