The regulation of the pentose phosphate pathway: remember Krebs

JI Ramos-Martinez - Archives of biochemistry and biophysics, 2017 - Elsevier
The changes in gene expression and posttranslational modifications of enzymes are
comprised in the concept of “coarse control” of the oxidative phase of the pentose phosphate …

The NF-κB pharmacopeia: Novel strategies to subdue an intractable target

D Verzella, J Cornice, P Arboretto, D Vecchiotti… - Biomedicines, 2022 - mdpi.com
NF-κB transcription factors are major drivers of tumor initiation and progression. NF-κB
signaling is constitutively activated by genetic alterations or environmental signals in many …

CDK4/6 regulate lysosome biogenesis through TFEB/TFE3

Q Yin, Y Jian, M Xu, X Huang, N Wang, Z Liu… - Journal of Cell …, 2020 - rupress.org
Lysosomes are degradation and signaling organelles that adapt their biogenesis to meet
many different cellular demands; however, it is unknown how lysosomes change their …

Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditis elegans

HC Yang, TL Chen, YH Wu, KP Cheng, YH Lin… - Cell death & …, 2013 - nature.com
Abstract Glucose 6-phosphate dehydrogenase (G6PD) deficiency, known as favism, is
classically manifested by hemolytic anemia in human. More recently, it has been shown that …

Selective inhibitor of nuclear export (SINE) compounds alter New World alphavirus capsid localization and reduce viral replication in mammalian cells

L Lundberg, C Pinkham, C de la Fuente… - PLoS Neglected …, 2016 - journals.plos.org
The capsid structural protein of the New World alphavirus, Venezuelan equine encephalitis
virus (VEEV), interacts with the host nuclear transport proteins importin α/β1 and CRM1 …

Glucose-6-phosphate dehydrogenase enhances antiviral response through downregulation of NADPH sensor HSCARG and upregulation of NF-κB signaling

YH Wu, DTY Chiu, HR Lin, HY Tang, ML Cheng, HY Ho - Viruses, 2015 - mdpi.com
Glucose-6-phosphate dehydrogenase (G6PD)-deficient cells are highly susceptible to viral
infection. This study examined the mechanism underlying this phenomenon by measuring …

Structure and functions of cellular redox sensor HSCARG/NMRAL1, a linkage among redox status, innate immunity, DNA damage response, and cancer

W Zang, X Zheng - Free Radical Biology and Medicine, 2020 - Elsevier
NmrA-like proteins are NAD (P)(H) interacting molecules whose structures are similar to that
of short-chain dehydrogenases. In this review, we focus on an NADP (H) sensor, HSCARG …

The regulation of the oxidative phase of the pentose phosphate pathway: new answers to old problems

R Barcia‐Vieitez, JI Ramos‐Martínez - IUBMB life, 2014 - Wiley Online Library
There is a paradox in the oxidizing phase of the phosphate pentose pathway that has not yet
been solved. The flow through the pathway is reduced in basal conditions; however, it must …

Importins and exportins regulating allergic immune responses

A Aggarwal, DK Agrawal - Mediators of inflammation, 2014 - Wiley Online Library
Nucleocytoplasmic shuttling of macromolecules is a well‐controlled process involving
importins and exportins. These karyopherins recognize and bind to receptor‐mediated …

Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1

J Wang, S Li, X Li, J Liu, J Yang, Y Li, W Li, Y Yang, J Li… - Brain, 2022 - academic.oup.com
Recent genome-wide association studies have reported multiple schizophrenia risk loci, yet
the functional variants and their roles in schizophrenia remain to be characterized. Here we …