Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
C Gao, J Jiang, Y Tan, S Chen - Signal transduction and targeted …, 2023 - nature.com
Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …
single-cell technologies have revealed that these reactive microglia were with high spatial …
Neuroinflammation is independently associated with brain network dysfunction in Alzheimer's disease
Brain network dysfunction is increasingly recognised in Alzheimer's disease (AD). However,
the causes of brain connectivity disruption are still poorly understood. Recently …
the causes of brain connectivity disruption are still poorly understood. Recently …
PET imaging of neuroinflammation in Alzheimer's disease
R Zhou, B Ji, Y Kong, L Qin, W Ren, Y Guan… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …
molecular imaging using positron emission tomography have provided insights into the time …
APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles
Animal studies suggest that the apolipoprotein E ε4 (APOE ε4) allele is a culprit of early
microglial activation in Alzheimer's disease (AD). Here, we tested the association between …
microglial activation in Alzheimer's disease (AD). Here, we tested the association between …
The use of neuroimaging techniques in the early and differential diagnosis of dementia
L Chouliaras, JT O'Brien - Molecular Psychiatry, 2023 - nature.com
Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …
disease modifying treatment for any of the most common types of dementia such as …
The role of inflammasomes in vascular cognitive impairment
There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …
Aging, frailty, and the microbiome—how dysbiosis influences human aging and disease
JP Haran, BA McCormick - Gastroenterology, 2021 - Elsevier
The human gut microbiome is a collection of bacteria, protozoa, fungi, and viruses that
coexist in our bodies and are essential in protective, metabolic, and physiologic functions of …
coexist in our bodies and are essential in protective, metabolic, and physiologic functions of …
Alzheimer's disease: etiology, neuropathology and pathogenesis
O Sheppard, M Coleman - Exon Publications, 2020 - exonpublications.com
Alzheimer's disease is the most common form of dementia and the most common
neurodegenerative disease. It manifests as a decline in short-term memory and cognition …
neurodegenerative disease. It manifests as a decline in short-term memory and cognition …
Role of diet and exercise in aging, Alzheimer's disease, and other chronic diseases
S Khemka, A Reddy, RI Garcia, M Jacobs… - Ageing Research …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by
memory loss and multiple cognitive impairments. Genetic mutations cause a small …
memory loss and multiple cognitive impairments. Genetic mutations cause a small …