Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

F Leng, P Edison - Nature Reviews Neurology, 2021 - nature.com
Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

C Gao, J Jiang, Y Tan, S Chen - Signal transduction and targeted …, 2023 - nature.com
Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Neuroinflammation is independently associated with brain network dysfunction in Alzheimer's disease

F Leng, R Hinz, S Gentleman, A Hampshire… - Molecular …, 2023 - nature.com
Brain network dysfunction is increasingly recognised in Alzheimer's disease (AD). However,
the causes of brain connectivity disruption are still poorly understood. Recently …

PET imaging of neuroinflammation in Alzheimer's disease

R Zhou, B Ji, Y Kong, L Qin, W Ren, Y Guan… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles

JP Ferrari-Souza, FZ Lussier, DT Leffa, J Therriault… - Science …, 2023 - science.org
Animal studies suggest that the apolipoprotein E ε4 (APOE ε4) allele is a culprit of early
microglial activation in Alzheimer's disease (AD). Here, we tested the association between …

The use of neuroimaging techniques in the early and differential diagnosis of dementia

L Chouliaras, JT O'Brien - Molecular Psychiatry, 2023 - nature.com
Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …

The role of inflammasomes in vascular cognitive impairment

L Poh, WL Sim, DG Jo, QN Dinh, GR Drummond… - Molecular …, 2022 - Springer
There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …

Aging, frailty, and the microbiome—how dysbiosis influences human aging and disease

JP Haran, BA McCormick - Gastroenterology, 2021 - Elsevier
The human gut microbiome is a collection of bacteria, protozoa, fungi, and viruses that
coexist in our bodies and are essential in protective, metabolic, and physiologic functions of …

Alzheimer's disease: etiology, neuropathology and pathogenesis

O Sheppard, M Coleman - Exon Publications, 2020 - exonpublications.com
Alzheimer's disease is the most common form of dementia and the most common
neurodegenerative disease. It manifests as a decline in short-term memory and cognition …

Role of diet and exercise in aging, Alzheimer's disease, and other chronic diseases

S Khemka, A Reddy, RI Garcia, M Jacobs… - Ageing Research …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by
memory loss and multiple cognitive impairments. Genetic mutations cause a small …