Inner ear delivery: Challenges and opportunities
B Szeto, H Chiang, C Valentini, M Yu… - Laryngoscope …, 2020 - Wiley Online Library
Objectives The treatment of inner ear disorders remains challenging due to anatomic
barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent …
barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent …
Improved inner ear drug delivery using hydrogel carriers
The management of inner ear disorders is troubled with obstacles, such as the precise
delivery of drug molecules to diseased cells. Due to the blood-labyrinth barrier (BLB) …
delivery of drug molecules to diseased cells. Due to the blood-labyrinth barrier (BLB) …
Novel 3D-printed hollow microneedles facilitate safe, reliable, and informative sampling of perilymph from guinea pigs
Background Inner ear diagnostics is limited by the inability to atraumatically obtain samples
of inner ear fluid. The round window membrane (RWM) is an attractive portal for accessing …
of inner ear fluid. The round window membrane (RWM) is an attractive portal for accessing …
Drug delivery device for the inner ear: ultra-sharp fully metallic microneedles
Drug delivery into the inner ear is a significant challenge due to its inaccessibility as a fluid-
filled cavity within the temporal bone of the skull. The round window membrane (RWM) is the …
filled cavity within the temporal bone of the skull. The round window membrane (RWM) is the …
Incorporation of bone morphogenetic protein-2 and osteoprotegerin in 3D-printed Ti6Al4V scaffolds enhances osseointegration under osteoporotic conditions
X Wang, Z Li, Z Wang, H Liu, Y Cui, Y Liu… - … in bioengineering and …, 2021 - frontiersin.org
Osteoporosis is an age-related metabolic disease that results in limited bone regeneration
capacity and excessive osteoclast activity. After arthroplasty in patients with osteoporosis …
capacity and excessive osteoclast activity. After arthroplasty in patients with osteoporosis …
3D printing of dual-cell delivery titanium alloy scaffolds for improving osseointegration through enhancing angiogenesis and osteogenesis
H Zhao, S Shen, L Zhao, Y Xu, Y Li, N Zhuo - BMC Musculoskeletal …, 2021 - Springer
Background The repair of large bone defects is a great challenge for orthopedics. Although
the development of three-dimensional (3D) printed titanium alloy (Ti6Al4V) implants with …
the development of three-dimensional (3D) printed titanium alloy (Ti6Al4V) implants with …
Development of thermosensitive poloxamer 407-based microbubble gel with ultrasound mediation for inner ear drug delivery
AH Liao, CP Shih, MW Li, YC Lin, HC Chuang… - Drug Delivery, 2021 - Taylor & Francis
ABSTRACTS Our previous study first investigated feasibility of applying ultrasound (US) and
microbubbles (MBs) via external auditory canal to facilitate drug delivery into inner ear …
microbubbles (MBs) via external auditory canal to facilitate drug delivery into inner ear …
Effect of ursodiol on alginate/PLL nanoparticles with non-ionic surfactant for gene delivery
Hearing loss is a widespread condition, affecting people from a range of demographics.
Gene therapy is an emerging method for the amelioration of this condition. Challenges …
Gene therapy is an emerging method for the amelioration of this condition. Challenges …
Impact of systemic versus intratympanic dexamethasone administration on the perilymph proteome
Glucocorticoids are the first-line treatment for sensorineural hearing loss, but little is known
about the mechanism of their protective effect or the impact of route of administration. The …
about the mechanism of their protective effect or the impact of route of administration. The …
Inner ear diagnostics and drug delivery via microneedles
Objectives: Precision medicine for inner ear disorders has seen significant advances in
recent years. However, unreliable access to the inner ear has impeded diagnostics and …
recent years. However, unreliable access to the inner ear has impeded diagnostics and …