Long non-coding RNAs and complex diseases: from experimental results to computational models

X Chen, CC Yan, X Zhang, ZH You - Briefings in bioinformatics, 2017 - academic.oup.com
LncRNAs have attracted lots of attentions from researchers worldwide in recent decades.
With the rapid advances in both experimental technology and computational prediction …

[HTML][HTML] Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis

G Hu, F Niu, BA Humburg, K Liao, S Bendi, S Callen… - Oncotarget, 2018 - ncbi.nlm.nih.gov
LncRNAs are long non-coding regulatory RNAs that are longer than 200 nucleotides. One of
the major functions of lncRNAs is the regulation of specific gene expression at multiple steps …

Comparison of RNA-Seq and microarray gene expression platforms for the toxicogenomic evaluation of liver from short-term rat toxicity studies

MS Rao, TR Van Vleet, R Ciurlionis, WR Buck… - Frontiers in …, 2019 - frontiersin.org
Gene expression profiling is a useful tool to predict and interrogate mechanisms of toxicity.
RNA-Seq technology has emerged as an attractive alternative to traditional microarray …

LDAP: a web server for lncRNA-disease association prediction

W Lan, M Li, K Zhao, J Liu, FX Wu, Y Pan… - …, 2017 - academic.oup.com
Motivation Increasing evidences have demonstrated that long noncoding RNAs (lncRNAs)
play important roles in many human diseases. Therefore, predicting novel lncRNA-disease …

A representation learning model based on variational inference and graph autoencoder for predicting lncRNA-disease associations

Z Shi, H Zhang, C Jin, X Quan, Y Yin - BMC bioinformatics, 2021 - Springer
Background Numerous studies have demonstrated that long non-coding RNAs are related
to plenty of human diseases. Therefore, it is crucial to predict potential lncRNA-disease …

Long noncoding RNA: a crosslink in biological regulatory network

Y Zhang, Y Tao, Q Liao - Briefings in bioinformatics, 2018 - academic.oup.com
Long noncoding RNAs (lncRNAs) had been defined as a novel class of functional RNAs
longer than 200 nucleotides around a decade ago. It is widely acknowledged that lncRNAs …

Exploring lncRNA-mediated regulatory networks in endometrial cancer cells and the tumor microenvironment: advances and challenges

P Dong, Y Xiong, J Yue, S JB Hanley, N Kobayashi… - Cancers, 2019 - mdpi.com
Recent studies have revealed both the promise and challenges of targeting long non-coding
RNAs (lncRNAs) to diagnose and treat endometrial cancer (EC). LncRNAs are upregulated …

Long non-coding RNAs: mechanisms, experimental, and computational approaches in identification, characterization, and their biomarker potential in cancer

A Chowdhary, V Satagopam, R Schneider - Frontiers in Genetics, 2021 - frontiersin.org
Long non-coding RNAs are diverse class of non-coding RNA molecules> 200 base pairs of
length having various functions like gene regulation, dosage compensation, epigenetic …

The long non-coding RNA Neat1 is an important mediator of the therapeutic effect of bexarotene on traumatic brain injury in mice

J Zhong, L Jiang, Z Huang, H Zhang, C Cheng… - Brain, behavior, and …, 2017 - Elsevier
Objective Bexarotene treatments exert neuroprotective effects on mice following traumatic
brain injury (TBI). The present study aims to investigate the potential roles of the long …

[HTML][HTML] Comprehensive landscape and future perspectives of long noncoding RNAs (lncRNAs) in colorectal cancer (CRC): Based on a bibliometric analysis

J He, W Wu - Non-coding RNA Research, 2023 - Elsevier
This review aimed to use bibliometric analysis to sort out, analyze and summarize the
knowledge foundation and hot topics in the field of long noncoding RNAs (lncRNAs) in …