Tobacco smoking is a major determinant of preventable morbidity and mortality worldwide.
More than a billion people smoke, and without major increases in cessation, at least half will …

Nicotine underlies tobacco addiction, influences tobacco use patterns, and is used as a
pharmacological aid to smoking cessation. The absorption, distribution and disposition …

The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for
smoking cessation, a potential medication for several diseases, and a useful probe drug for …

Rationale This review provides insight for the judicious selection of nicotine dose ranges
and routes of administration for in vivo studies. The literature is replete with reports in which …

Neonicotinoids are a class of insecticides that exert their effect through a specific action on
neuronal nicotinic acetylcholine receptors (nAChRs). The success of these insecticides is …

Almost all degenerative diseases of the CNS are associated with chronic inflammation. A
central step in this process is the activation of brain mononuclear phagocyte cells, called …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion
channels present in the central and peripheral nervous systems, that are permeable to mono …

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels and can be
divided into two groups: muscle receptors, which are found at the skeletal neuromuscular …

Currently, acetylcholinesterase (AChE) inhibitors are the most promising class of drugs for
the treatment of Alzheimer's disease (AD). Galantamine is a reversible, competitive, tertiary …