Reactive oxygen species (ROS) are metabolic byproducts that are necessary for
physiological function but can be toxic at high levels. Levels of these oxidative stressors …

Patients with Alzheimer's disease (AD) present with both extracellular amyloid-β (Aβ)
plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years …

Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's
disease (AD) and, as such, have become the focus of therapeutic development. Recent …

Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark
of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to …

Abstract cGAS senses microbial and host-derived double-stranded DNA in cytoplasm to
trigger cellular innate immune response in a STING-dependent manner; however, it remains …

Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the
stability of the genome across the long lifespan of postmitotic neurons,,,–. Whether neurons …

Defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative
diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic …

Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …

The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …

Over the past 10 years, the development and convergence of microbial opsin engineering,
modular genetic methods for cell-type targeting and optical strategies for guiding light …