Cholesterol, the most important sterol in mammals, helps maintain plasma membrane fluidity
and is a precursor of bile acids, oxysterols, and steroid hormones. Cholesterol in the body is …

Protein ubiquitination is of great cellular importance through its central role in processes
such as degradation, DNA repair, endocytosis and inflammation. Canonical ubiquitination …

Genetic, epidemiologic, and biochemical evidence suggests that predisposition to
Alzheimer's disease (AD) may arise from altered cholesterol metabolism, although the …

Medical Biochemistry is supported by over forty years of teaching experience, providing
coverage of basic biochemical concepts, including the structure and physical and chemical …

Lipids are essential molecules that play key roles in cell physiology by serving as structural
components, for storage of energy, and in signal transduction. Hence, efficient regulation …

CD8+ T cells can be polarized into IL-9–secreting (Tc9) cells. We previously showed that
adoptive therapy using tumor-specific Tc9 cells generated stronger antitumor responses in …

Cholesterol is an essential molecule in cellular membranes, but too much cholesterol can be
toxic. Therefore, mammalian cells have developed complex mechanisms to remove excess …

Ubiquitin linkage to cysteine is an unconventional modification targeting protein for
degradation. However, the physiological regulation of cysteine ubiquitylation is still …

Cholesterol metabolism operates autonomously within the central nervous system (CNS),
where the majority of cholesterol resides in myelin. We demonstrate that TDP-43, the …

Mammalian target of rapamycin (mTOR) senses changes in nutrient status and stimulates
the autophagic process to recycle amino acids. However, the impact of nutrient stress on …