Assembly of spherical viruses, which may involve hundreds of components, is not well
understood on a biological or a physical basis. Recently, tremendous progress has been …

During the late stage of the viral life cycle, HIV-1 Gag assembles into a spherical immature
capsid, and undergoes budding, release, and maturation. Here we review events involved in …

The major structural components of HIV-1 are encoded as a single polyprotein, Gag, which
is sufficient for virus particle assembly. Initially, Gag forms an approximately spherical shell …

The human immunodeficiency virus type 1 initially assembles and buds as an immature
particle that is organized by the viral Gag polyprotein. Gag is then proteolyzed to produce …

UV spectra of viruses are complicated by overlapping protein and RNA absorbance and
light scattering. We describe and validate methodology for estimating RNA and protein …

The assembly of retroviruses such as HIV-1 is driven by oligomerization of their major
structural protein, Gag. Gag is a multidomain polyprotein including three conserved folded …

Assembly of virus capsids and surface proteins must be regulated to ensure that the
resulting complex is an infectious virion. In this review, we examine assembly of virus …

The role of nucleocapsid protein (NC) in the early steps of retroviral replication appears
largely that of a facilitator for reverse transcription and integration. Using a wide variety of …

ABSTRACT APOBEC3G exerts its antiviral activity by targeting to retroviral particles and
inducing viral DNA hypermutations in the absence of Vif. However, the mechanism by which …

The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and
cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a …