Aberrant c‐Met activity has been implicated in the development of hepatocellular carcinoma
(HCC), suggesting that c‐Met inhibition may have therapeutic potential. However, clinical …

Stem cell systems regulate tissue development and maintenance. The germline stem cell
system is essential for animal reproduction, controlling both the timing and number of …

Spermatogenesis is a complex and dynamic cellular differentiation process critical to male
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …

Autophagy involves the sequestration of cytoplasmic contents in a double-membrane
structure referred to as the autophagosome and the degradation of its contents upon …

It is emerging that autophagy-related proteins regulate the adaptive response to DNA
damage in maintaining genome stability at multiple pathways. Here, we discuss recent …

Abstract Mutations in Cu/Zn–superoxide dismutase 1 (SOD1) are linked to amyotrophic
lateral sclerosis (ALS). Using a line of ALS-related mutant human SOD1 (hSOD1) transgenic …

With the large-scale production and use of plastic products, the global plastic pollution
problem is becoming more and more serious. The plasticizer di (2-ethylhexyl) phthalate …

Abstract DEHP (di (2-ethylhexyl) phthalate) is an endocrine disruptor commonly found in
plastic products that has been associated with reproduction alterations, but the effect of …

Notch signaling plays an emerging role in the regulation of immune cell development and
function during inflammatory response. Activation of the ras homolog gene family member …

The proper accumulation and maintenance of stem cells is critical for organ development
and homeostasis. The Notch signaling pathway maintains stem cells in diverse organisms …