Antibodies play a critical role in linking the adaptive immune response to the innate immune
system. In humans, antibodies are categorized into five classes, IgG, IgM, IgA, IgE, and IgD …

Spleen tyrosine kinase (Syk) is a cytoplasmic protein tyrosine kinase well known for its
ability to couple immune cell receptors to intracellular signaling pathways that regulate …

Targeting of immunoglobulin E (IgE) represents an interesting approach for the treatment of
allergic disorders. A high-affinity monoclonal anti-IgE antibody, ligelizumab, has recently …

Immunoglobulin E (IgE) antibodies are well known for their role in mediating allergic
reactions, and their powerful effector functions activated through binding to Fc receptors …

abstract IgE and mast cells play a pivotal role in various allergic diseases, including asthma,
allergic rhinitis, and urticaria. Treatment with omalizumab, a monoclonal anti-IgE antibody …

IgG4, the least represented human IgG subclass in serum, is an intriguing antibody with
unique biological properties, such as the ability to undergo Fab‐arm exchange and limit …

Over the last 2 decades, omalizumab is the only anti-IgE antibody that has been approved
for asthma and chronic spontaneous urticaria (CSU). Ligelizumab, a higher-affinity anti-IgE …

IgE, the key molecule in atopy has been shown to bind two receptors, FcεRI, the high‐affinity
receptor, and FcεRII (CD23), binding IgE with lower affinity. Whereas cross‐linking of IgE on …

Immunoglobulin E (IgE) is well known for its role in allergic disease, the manifestations of
which are mediated through its two Fc receptors, Fcε RI and CD 23 (Fcε RII). IgE and its …

Current asthma therapy is based on the use of adrenergic bronchodilator and anti-
inflammatory drugs the specificity, efficacy, duration of action, and safety of which have been …