Cancer is a multistep disease driven by the activation of specific oncogenic pathways
concomitantly with the loss of function of tumor suppressor genes that act as sentinels to …

Animal models of Parkinson's disease (PD) have proved highly effective in the discovery of
novel treatments for motor symptoms of PD and in the search for clues to the underlying …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common age-related
neurodegenerative disorders, affecting several millions of aged people globally. Among …

Mitochondria are involved in a variety of cellular functions, including ATP production, amino
acid and lipid biogenesis and breakdown, signalling and apoptosis,,. Mitochondrial …

Current high‐throughput screening methods for drug discovery rely on the existence of
targets. Moreover, most of the hits generated during screenings turn out to be invalid after …

Mutations in PINK1 and PARK2 cause autosomal recessive parkinsonism, a
neurodegenerative disorder that is characterized by the loss of dopaminergic neurons. To …

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder with
unknown etiology. It is marked by widespread neurodegeneration in the brain with profound …

Neuroinflammation is an important factor contributing to cognitive impairment and
neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) …

As populations benefit from increasing lifespans, neurodegenerative diseases have
emerged as a critical health concern. How can the fruit fly, Drosophila melanogaster …

Cellular quality control systems have gained much attention in recent decades. Among
these, autophagy is a natural self-preservation mechanism that continuously eliminates toxic …