TSH via cAMP, and various growth factors, in cooperation with insulin or IGF-I stimulate cell
cycle progression and proliferation in various thyrocyte culture systems, including rat thyroid …

The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates
active iodide transport into the thyroid gland and into several extrathyroidal tissues, in …

The sodium iodide symporter (NIS) is responsible for thyroidal, salivary, gastric, intestinal
and mammary iodide uptake. It was first cloned from the rat in 1996 and shortly thereafter …

Thyrotropin (TSH) is considered the main regulator of thyrocyte differentiation and
proliferation. Thus, the characterization of the different signaling pathways triggered by TSH …

p38 mitogen-activated protein kinases (p38-MAPKs) are activated by cytokines, cellular
stresses, growth factors, and hormones. We show here that p38-MAPKs are activated upon …

The thyroid target Ag for disease-inducing autoantibodies in Graves' disease is the receptor
for thyroid-stimulating hormone (TSH), but little is known about the molecular basis of this …

Stimulation of the thyrotropin receptor (TSHR) activates G proteins of all four subfamilies (G
s, G i/o, G q/11, and G 12/13). Whereas G s/cAMP-dependent cellular responses upon TSHR …

Thyroid-stimulating hormone (TSH) action in adipose tissue remains largely unknown. Our
previous work indicates that human preadipocytes express functional TSH receptor (TSHR) …

We have investigated the role of the different classes of MAPKs, ie. ERKs, c-Jun N-terminal
kinases (JNKs), and p38 MAPK in the proliferation of dog and human thyroid epithelial cells …

Interleukin-6 (IL-6) is a multifunctional cytokine involved in autoimmune thyroid diseases
such as Hashimoto's thyroiditis and Graves' disease. IL-6 is produced by infiltrating immune …