Understanding of the biological basis for susceptibility to malaria in pregnancy was recently
advanced by the discovery that erythrocytes infected with Plasmodium falciparum …

Plasmodium falciparum imposes an enormous burden upon the developing world, with 300
to 500 million cases and 1 to 2 million deaths per year (94). Despite extensive research …

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate
receptor-and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody …

The malaria parasite Plasmodium falciparum exports several hundred proteins into the
infected erythrocyte that are involved in cellular remodeling and severe virulence. The …

Plasmodium falciparum VAR2CSA binds to chondroitin sulfate A (CSA) on the surface of the
syncytiotrophoblast during placental malaria. This interaction facilitates placental …

Reverse genetics is key to understanding protein function, but the mechanistic connection
between a gene of interest and the observed phenotype is not always clear. Here we …

Placental malaria (PM) due to Plasmodium falciparum is a major cause of maternal, fetal
and infant mortality, but the mechanisms of pathogenesis and protective immunity are …

Studies on immunologic memory in animal models and especially in the human system are
instrumental to identify mechanisms and correlates of protection necessary for vaccine …

A proportion of transplant recipients can spontaneously accept their grafts in the absence of
immunosuppression (operational tolerance). Previous studies identified blood …

Placental accumulation of Plasmodium falciparum infected erythrocytes results in maternal
anemia, low birth weight, and pregnancy loss. The parasite protein VAR2CSA facilitates the …