Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal
monogenic disorder. It has large inter-and intra-familial variability explained to a large extent …

Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace
normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease …

Several developmental pathways contribute to processes that regulate tissue growth and
organ size. The Hippo pathway has emerged as one such critical regulator. However, how …

To elucidate the molecular pathways that modulate renal cyst growth in ADPKD, we
performed global gene profiling on cysts of different size (< 1 ml, n= 5; 10–20 ml, n= 5;> 50 …

It is 20 years since the identification of PKD1, the major gene mutated in autosomal
dominant polycystic kidney disease (ADPKD), followed closely by the cloning of PKD2 …

Glioblastoma is the most aggressive primary brain tumor in adults and due to the invasive
nature cannot be completely removed. The WNT inhibitory factor 1 (WIF1), a secreted …

Vinculin was identified as a component of adherens junctions 30 years ago, yet its function
there remains elusive. Deletion studies are consistent with the idea that vinculin is important …

Abnormalities in the primary cilium perturb signaling pathways that regulate renal epithelial
cell growth and differentiation and lead to the formation of kidney cysts. Acute kidney injury …

Cystic kidney disease represents a major cause of end-stage renal disease, yet the
molecular mechanisms of pathogenesis remain largely unclear. Recent emphasis has been …

Autosomal dominant polycystic disease (ADPKD) is the most common form of inherited
kidney disease that results in renal failure. The understanding of the pathogenesis of …