Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel
Cyclic nucleotide-gated (CNG) channels transduce chemical signals into electrical signals in
sensory receptors and neurons. They are activated by cGMP or cAMP, which bind to the …
sensory receptors and neurons. They are activated by cGMP or cAMP, which bind to the …
Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels
Recent years have seen an outpouring of atomic or near atomic resolution structures of
cyclic nucleotide-gated (CNG) channels, captured in closed, transition, pre-open, partially …
cyclic nucleotide-gated (CNG) channels, captured in closed, transition, pre-open, partially …
Direct single-molecule detection of CoA-SH and ATP by the membrane proteins TMEM120A and TMEM120B
C Zhao, M Chen, X Liu, W Yuan, K Li, Y Wang, C Chen… - Nanoscale, 2024 - pubs.rsc.org
Membrane proteins are vital resources for developing biosensors. TMEM120A is a
membrane protein associated with human pain transmission and lipid metabolism, and …
membrane protein associated with human pain transmission and lipid metabolism, and …
Single-Molecule FRET Analyses of NMDA Receptors
RJ Durham, V Jayaraman - NMDA Receptors: Methods and Protocols, 2024 - Springer
Single-molecule fluorescence resonance energy transfer (smFRET) enables the real-time
observation of conformational changes in a single protein molecule of interest. These …
observation of conformational changes in a single protein molecule of interest. These …
Ligand-Coupled Conformational Changes in a Cyclic Nucleotide-Gated Ion Channel Revealed by Time-Resolved Transition Metal Ion FRET
P Eggan, SE Gordon, WN Zagotta - bioRxiv, 2024 - biorxiv.org
Cyclic nucleotide-binding domain (CNBD) ion channels play crucial roles in cellular-
signaling and excitability and are regulated by the direct binding of cyclic adenosine-or …
signaling and excitability and are regulated by the direct binding of cyclic adenosine-or …