Erythro-myeloid progenitors:“definitive” hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells
JM Frame, KE McGrath, J Palis - Blood Cells, Molecules, and Diseases, 2013 - Elsevier
Erythro-myeloid progenitors (EMP) serve as a major source of hematopoiesis in the
developing conceptus prior to the formation of a permanent blood system. In this review, we …
developing conceptus prior to the formation of a permanent blood system. In this review, we …
[HTML][HTML] Myb proteins: angels and demons in normal and transformed cells
Y Zhou, SA Ness - Frontiers in bioscience: a journal and virtual …, 2011 - ncbi.nlm.nih.gov
A key regulator of proliferation, differentiation and cell fate, the c-Myb transcription factor
regulates the expression of hundreds of genes and is in turn regulated by numerous …
regulates the expression of hundreds of genes and is in turn regulated by numerous …
Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells
Notch1 regulates gene expression by associating with the DNA-binding factor RBPJ and is
oncogenic in murine and human T-cell progenitors. Using ChIP-Seq, we find that in human …
oncogenic in murine and human T-cell progenitors. Using ChIP-Seq, we find that in human …
NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells
NOTCH signaling is required for the arterial specification and formation of hematopoietic
stem cells (HSCs) and lympho-myeloid progenitors in the embryonic aorta-gonad …
stem cells (HSCs) and lympho-myeloid progenitors in the embryonic aorta-gonad …
Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition
CO Lizama, JS Hawkins, CE Schmitt, FL Bos… - Nature …, 2015 - nature.com
Abstract Changes in cell fate and identity are essential for endothelial-to-haematopoietic
transition (EHT), an embryonic process that generates the first adult populations of …
transition (EHT), an embryonic process that generates the first adult populations of …
Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells
EYN Lam, CJ Hall, PS Crosier… - Blood, The Journal …, 2010 - ashpublications.org
Blood cells of an adult vertebrate are continuously generated by hematopoietic stem cells
(HSCs) that originate during embryonic life within the aorta-gonad-mesonephros region …
(HSCs) that originate during embryonic life within the aorta-gonad-mesonephros region …
Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved
C Soza-Ried, I Hess, N Netuschil… - Proceedings of the …, 2010 - National Acad Sciences
The transcription factor c-myb has emerged as one of the key regulators of vertebrate
hematopoiesis. In mice, it is dispensable for primitive stages of blood cell development but …
hematopoiesis. In mice, it is dispensable for primitive stages of blood cell development but …
Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics
B Hadland, B Varnum-Finney, S Dozono… - Nature …, 2022 - nature.com
Hematopoietic stem cells (HSCs) develop from hemogenic endothelium within embryonic
arterial vessels such as the aorta of the aorta-gonad-mesonephros region (AGM). To identify …
arterial vessels such as the aorta of the aorta-gonad-mesonephros region (AGM). To identify …
A network of epigenetic regulators guides developmental haematopoiesis in vivo
HT Huang, KL Kathrein, A Barton, Z Gitlin… - Nature cell …, 2013 - nature.com
The initiation of cellular programs is orchestrated by key transcription factors and chromatin
regulators that activate or inhibit target gene expression. To generate a compendium of …
regulators that activate or inhibit target gene expression. To generate a compendium of …
Zebrafish nephrogenesis involves dynamic spatiotemporal expression changes in renal progenitors and essential signals from retinoic acid and irx3b
RA Wingert, AJ Davidson - Developmental Dynamics, 2011 - Wiley Online Library
Kidney nephrons are composed of proximal and distal tubule segments that perform unique
roles in excretion. The developmental pathways that establish nephron segment identities …
roles in excretion. The developmental pathways that establish nephron segment identities …