Erythro-myeloid progenitors (EMP) serve as a major source of hematopoiesis in the
developing conceptus prior to the formation of a permanent blood system. In this review, we …

A key regulator of proliferation, differentiation and cell fate, the c-Myb transcription factor
regulates the expression of hundreds of genes and is in turn regulated by numerous …

Notch1 regulates gene expression by associating with the DNA-binding factor RBPJ and is
oncogenic in murine and human T-cell progenitors. Using ChIP-Seq, we find that in human …

NOTCH signaling is required for the arterial specification and formation of hematopoietic
stem cells (HSCs) and lympho-myeloid progenitors in the embryonic aorta-gonad …

Abstract Changes in cell fate and identity are essential for endothelial-to-haematopoietic
transition (EHT), an embryonic process that generates the first adult populations of …

Blood cells of an adult vertebrate are continuously generated by hematopoietic stem cells
(HSCs) that originate during embryonic life within the aorta-gonad-mesonephros region …

The transcription factor c-myb has emerged as one of the key regulators of vertebrate
hematopoiesis. In mice, it is dispensable for primitive stages of blood cell development but …

Hematopoietic stem cells (HSCs) develop from hemogenic endothelium within embryonic
arterial vessels such as the aorta of the aorta-gonad-mesonephros region (AGM). To identify …

The initiation of cellular programs is orchestrated by key transcription factors and chromatin
regulators that activate or inhibit target gene expression. To generate a compendium of …

Kidney nephrons are composed of proximal and distal tubule segments that perform unique
roles in excretion. The developmental pathways that establish nephron segment identities …