The opioid G-protein coupled receptors (GPCRs) strongly modulate many of the central
nervous system structures that contribute to major neurological and psychiatric disorders …

A wealth of neuromodulatory transmitters regulate synaptic circuits in the brain. Their mode
of signaling, often called volume transmission, differs from classical synaptic transmission in …

Photoactivatable neuropeptides offer a robust stimulus–response relationship that can drive
mechanistic studies into the physiological mechanisms of neuropeptidergic transmission …

Abstract Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide
with key regulatory functions in several central behavioral processes including motivation …

Neural communication requires both fast-acting neurotransmitters and neuromodulators that
function on slower timescales to communicate. Endogenous bioactive peptides, often called" …

Neurons typically release both a neurotransmitter and one or more neuropeptides, but how
these signals are integrated within neural circuits to generate and tune behaviors remains …

Major depressive disorder (MDD) is a serious disease and a burden to patients, families and
society. Rodent experiments and human studies suggest that several neuropeptide systems …

The significance of transient neuropeptide expression during postnatal brain development is
unknown. Here, we show that galanin expression in the ventrobasal thalamus of infant mice …

Throughout the 20th Century, regulatory peptide discovery advanced from the identification
of gut hormones to the extraction and characterization of hypothalamic hypophysiotropic …

Peptide-drug conjugates have achieved considerable development and application as a
novel strategy for targeted delivery of anticancer drugs. Bioactive peptides induced calcium …