In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal
roles in many aspects of the immune response, including immune cell development and …

Tripartite motif (TRIM) family proteins, most of which have E3 ubiquitin ligase activities, have
various functions in cellular processes including intracellular signaling, development …

Tripartite motif (TRIM) proteins are a versatile family of ubiquitin E3 ligases involved in a
multitude of cellular processes. Studies in recent years have demonstrated that many TRIM …

Although radiotherapy can promote antitumour immunity, the mechanisms underlying this
phenomenon remain unclear. Here, we demonstrate that the expression of the E3 ubiquitin …

The mammalian innate immune system detects the presence of microbial infection through
germ line-encoded pattern recognition receptors (PRRs). Toll-like receptors, retinoic acid …

Eukaryotic stress granules (SGs) are highly dynamic assemblies of untranslated mRNAs
and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress …

The present paradigms of selective autophagy in mammalian cells cannot fully explain the
specificity and selectivity of autophagic degradation. In this paper, we report that a subset of …

Abstract Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–
Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I …

Research on innate immune signaling and regulation has recently focused on pathogen
recognition receptors (PRRs) and their signaling pathways. Members of PRRs sense …