The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …

Multiple type I interferons and interferon-γ (IFN-γ) are expressed under physiological
conditions and are increased by stress and infections, and in autoinflammatory and …

Effectiveness of checkpoint immunotherapy in cancer can be undermined by
immunosuppressive tumor-associated macrophages (TAMs) with an M2 phenotype …

IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory
responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the …

The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally
identified as a nuclear factor that binds and activates the promoters of type I interferon …

Despite the remarkable advances in therapeutics for rheumatoid arthritis (RA), a large
number of patients still lack effective countermeasures. Recently, the reprogramming of …

Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …

During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal
uterus and modify its vessels. In particular, remodeling of the spiral arteries by EVTs is …

Monocytes and macrophages provide defence against pathogens and danger signals.
These cells respond to stimulation in a fast and stimulus-specific manner by utilizing …

Macrophages are first responders for the immune system. In this role, they have both effector
functions for neutralizing pathogens and sentinel functions for alerting other immune cells of …