Antimicrobial peptides, which have been isolated from many bacteria, fungi, plants,
invertebrates and vertebrates, are an important component of the natural defenses of most …

The Candida albicans cell wall maintains the structural integrity of the organism in addtion to
providing a physical contact interface with the environment. The major components of the …

In recent decades, invasive fungal infections have been increasing significantly, contributing
to high incidences and mortality in immunosuppressed patients. Candida albicans (C …

In recent decades, pathogenic fungi have become a serious threat to human health, leading
to major efforts aimed at characterizing new agents for improved treatments. Promising in …

Maintenance of proper intracellular concentrations of monovalent cations, mainly sodium
and potassium, is a requirement for survival of any cell. In the budding yeast Saccharomyces …

The candidacidal activity of histatin 5 is initiated through cell wall binding, followed by
translocation and intracellular targeting, while the halocidin peptide exerts its activity by …

As the proper maintenance of intracellular potassium and sodium concentrations is vital for
cell growth, all living organisms have developed a cohort of strategies to maintain proper …

Summary Salivary histatin 5 (Hst 5) is a cationic salivary protein with high fungicidal activity
against Candida albicans. Binding to the cell wall followed by intracellular translocation is …

Fungicidal activity of Hst 5 is initiated by binding to cell surface proteins on Candida
albicans, followed by intracellular transport to cytoplasmic effectors leading to cell death. As …

To maintain optimal intracellular concentrations of alkali–metal–cations, yeast cells use a
series of influx and efflux systems. Nonconventional yeast species have at least three …