The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

VE-cadherin is a component of endothelial cell-to-cell adherens junctions, and it has a key
role in the maintenance of vascular integrity. During embryo development, VE-cadherin is …

The endothelial monolayer partitioning underlying tissue from blood components in the
vessel wall maintains tissue fluid balance and host defense through dynamically opening …

The endothelium forms a selective semi-permeable barrier controlling bidirectional transfer
between blood vessel and irrigated tissues. This crucial function relies on the dynamic …

Dysregulation of neuronal excitability underlies the pathogenesis of tauopathies, including
frontotemporal dementia (FTD) with tau inclusions. A majority of FTD-causing tau mutations …

Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …

Endothelial cells line all blood vessels, where they coordinate blood vessel formation and
the blood-tissue barrier via regulation of cell-cell junctions. The nucleus also regulates …

The regulation of microtubule dynamics is critical to ensure essential cell functions, such as
proper segregation of chromosomes during mitosis or cell polarity and migration. End …

Regulation of the microtubule cytoskeleton is of pivotal importance for neuronal
development and function. One such regulatory mechanism centers on microtubule plus …

Human cytomegalovirus (HCMV), a leading cause of congenital birth defects, forms an
unusual cytoplasmic virion maturation site termed the" assembly compartment"(AC). Here …