Radiomics is the extraction of predefined mathematic features from medical images for
predicting variables of clinical interest. Recent research has demonstrated that radiomics …

Sarcomas are heterogeneous bone and soft tissue cancers representing the second most
common tumor type in children and adolescents. Histology and genetic profiling discovered …

Abstract CIC:: DUX4 sarcoma (CDS) is a rare but highly aggressive undifferentiated small
round cell sarcoma driven by a fusion between the tumor suppressor Capicua (CIC) and …

In the past two decades, technological advances have brought unprecedented insights into
the paediatric cancer genome revealing characteristics distinct from those of adult cancer …

Purpose: Despite limited genetic and histologic heterogeneity, Ewing sarcoma (EwS) tumor
cells are transcriptionally heterogeneous and display varying degrees of mesenchymal …

The mechanistic basis for the metastasis of Ewing sarcomas remains poorly understood, as
these tumors harbor few mutations beyond the chromosomal translocation that initiates the …

Simple Summary Ewing sarcoma (EwS) is a highly aggressive and metastatic cancer in
children and adolescents. Canonical therapy mainly comprises the combination of intensive …

Bone and soft tissue tumors are generally classified into complex karyotype sarcomas
versus those with recurrent genetic alterations, often in the form of gene fusions. In this …

The advent of novel cancer immunotherapy approaches is revolutionizing the treatment for
cancer. Current small animal models for most cancers are syngeneic or genetically …

We describe exciting recent advances in fusion-driven sarcoma etiology, from an
epigenetics perspective. By exploring the current state of the field, we identify and describe …