[HTML][HTML] Mitochondrial function in immune cells in health and disease
One of the main functions of mitochondria is production of ATP for cellular energy needs,
however, it becomes more recognized that mitochondria are involved in differentiation and …
however, it becomes more recognized that mitochondria are involved in differentiation and …
Emerging role of lipid metabolism alterations in Cancer stem cells
M Yi, J Li, S Chen, J Cai, Y Ban, Q Peng, Y Zhou… - Journal of Experimental …, 2018 - Springer
Abstract Background Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a
small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the …
small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the …
Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation
Fructose intake has increased substantially throughout the developed world and is
associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our …
associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our …
[HTML][HTML] Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells
Lipids, the basic components of the cell membrane, execute fundamental roles in almost all
the cell activities including cell-cell recognition, signalling transduction and energy supplies …
the cell activities including cell-cell recognition, signalling transduction and energy supplies …
Metabolic reprogramming in immune response and tissue inflammation
Innate and adaptive immunity participate in and regulate numerous human diseases.
Increasing evidence implies that metabolic reprogramming mediates immune cell functional …
Increasing evidence implies that metabolic reprogramming mediates immune cell functional …
Aberrant lipid metabolism as an emerging therapeutic strategy to target cancer stem cells
Emerging evidence in cancer metabolomics has identified reprogrammed metabolic
pathways to be a major hallmark of cancer, among which deregulated lipid metabolism is a …
pathways to be a major hallmark of cancer, among which deregulated lipid metabolism is a …
Epigenomic and transcriptomic analyses reveal differences between low-grade inflammation and severe exhaustion in LPS-challenged murine monocytes
Emerging studies suggest that monocytes can be trained by bacterial endotoxin to adopt
distinct memory states ranging from low-grade inflammation to immune exhaustion. While …
distinct memory states ranging from low-grade inflammation to immune exhaustion. While …
[HTML][HTML] Aging impairs mitochondrial respiratory capacity in classical monocytes
Aging is a critical healthcare concern, with age-related inflammation disposing individuals to
a variety of diseases. Monocytes are affected by the aging process, with increased …
a variety of diseases. Monocytes are affected by the aging process, with increased …
MCL-1 is a master regulator of cancer dependency on fatty acid oxidation
MS Prew, U Adhikary, DW Choi, EP Portero, JA Paulo… - Cell reports, 2022 - cell.com
MCL-1 is an anti-apoptotic BCL-2 family protein essential for survival of diverse cell types
and is a major driver of cancer and chemoresistance. The mechanistic basis for the …
and is a major driver of cancer and chemoresistance. The mechanistic basis for the …
MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
MYC activates different metabolic programs in a cell-type-and cell-status-dependent
manner. However, the role of MYC in inflammatory macrophages has not yet been …
manner. However, the role of MYC in inflammatory macrophages has not yet been …