Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Current treatment options for foot ulcers, a serious and prevalent complication of diabetes,
remain nonspecific. In this Perspective, we present recent advances in understanding the …

Endothelial malfunction is responsible for impaired angiogenesis in diabetic patients,
thereby causing the delayed healing progress of diabetic wounds. Exosomes or …

Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response
to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are …

Diabetic wound healing remains a critical challenge due to its vulnerability to multidrug-
resistant (MDR) bacterial infection, as well as the hyperglycemic and oxidative wound …

The wound healing and management are widely concerned in global military and civil
settings, which lays a huge public medical burden on the medical systems of every states …

Chronic wounds in diabetes undergo a lifetime risk of developing into diabetic foot ulcers.
Oxygen is crucial to wound healing by regulating cell proliferation, migration, and …

Lack of oxygen, reduced vascularization, elevated oxidative stress, and infection are critical
clinical hallmarks of non-healing chronic diabetic wounds. Therefore, delivering oxygen …

The human health is still threatened by refractory keratitis and diabetic foot ulcers caused by
bacterial infections, hypoxia, and chronic inflammation, so that patients are exposed to the …

Chronic diabetic wounds are at lifelong risk of developing diabetic foot ulcers owing to
severe hypoxia, excessive reactive oxygen species (ROS), a complex inflammatory …