[HTML][HTML] Non-canonical G protein signaling
B Nürnberg, S Beer-Hammer, E Reisinger… - Pharmacology & …, 2024 - Elsevier
The original paradigm of classical-also referred to as canonical-cellular signal transduction
of heterotrimeric G proteins (G protein) is defined by a hierarchical, orthograde interaction of …
of heterotrimeric G proteins (G protein) is defined by a hierarchical, orthograde interaction of …
[HTML][HTML] Sequence-directed concentration of G protein-coupled receptors in COPII vesicles
G protein-coupled receptors (GPCRs) constitute the largest superfamily of plasma
membrane signaling proteins. However, virtually nothing is known about their recruitment to …
membrane signaling proteins. However, virtually nothing is known about their recruitment to …
The ufmylation cascade controls COPII recruitment, anterograde transport, and sorting of nascent GPCRs at ER
Ufmylation is implicated in multiple cellular processes, but little is known about its functions
and regulation in protein trafficking. Here, we demonstrate that the genetic depletion of core …
and regulation in protein trafficking. Here, we demonstrate that the genetic depletion of core …
Segregation of nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction
X Xu, L Qiu, M Zhang, G Wu - Journal of Cell Science, 2024 - journals.biologists.com
ABSTRACT G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell
surface signaling proteins that share a common structural topology. When compared with …
surface signaling proteins that share a common structural topology. When compared with …
Gβγ signaling regulates microtubule-dependent control of Golgi integrity
K Rajanala, PB Wedegaertner - Cellular signalling, 2023 - Elsevier
Gβγ subunits regulate several non-canonical functions at distinct intracellular organelles.
Previous studies have shown that Gβγ signaling at the Golgi is necessary to mediate …
Previous studies have shown that Gβγ signaling at the Golgi is necessary to mediate …
[HTML][HTML] Protocol to visualize and quantify the COPII concentration and anterograde transport of nascent G protein-coupled receptors
X Xu, G Wu - STAR protocols, 2024 - Elsevier
Here, we present a protocol for visualization and quantification of the recruitment of newly
synthesized G protein-coupled receptors (GPCRs) to coat protein complex II vesicles and …
synthesized G protein-coupled receptors (GPCRs) to coat protein complex II vesicles and …
Compartmentalized Phospholipase C Signaling as a Hub That Mediates-adrenergic Receptor Crosstalk in Cardiac Hypertrophy
W Wei - 2023 - deepblue.lib.umich.edu
β-adrenergic receptors are G protein coupled receptors that are critical regulators of cardiac
output during sympathetic stimulation. Chronic stimulation of the adrenergic system of the …
output during sympathetic stimulation. Chronic stimulation of the adrenergic system of the …