The original paradigm of classical-also referred to as canonical-cellular signal transduction
of heterotrimeric G proteins (G protein) is defined by a hierarchical, orthograde interaction of …

G protein-coupled receptors (GPCRs) constitute the largest superfamily of plasma
membrane signaling proteins. However, virtually nothing is known about their recruitment to …

Ufmylation is implicated in multiple cellular processes, but little is known about its functions
and regulation in protein trafficking. Here, we demonstrate that the genetic depletion of core …

ABSTRACT G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell
surface signaling proteins that share a common structural topology. When compared with …

Gβγ subunits regulate several non-canonical functions at distinct intracellular organelles.
Previous studies have shown that Gβγ signaling at the Golgi is necessary to mediate …

Here, we present a protocol for visualization and quantification of the recruitment of newly
synthesized G protein-coupled receptors (GPCRs) to coat protein complex II vesicles and …

β-adrenergic receptors are G protein coupled receptors that are critical regulators of cardiac
output during sympathetic stimulation. Chronic stimulation of the adrenergic system of the …