CRISPR and CRISPR-associated (Cas) protein, as components of microbial adaptive
immune system, allows biologists to edit genomic DNA in a precise and specific way …

In recent years, the innovation of gene-editing tools such as the CRISPR/Cas9 system
improves the translational gap of treatments mediated by gene therapy. The privileges of …

Human telomerase reverse transcriptase (hTERT) has been found to be closely related to
tumor transformation, growth, and metastasis. Thus, the delivery of hTERT small interfering …

Since the dawn of life, bacteria and phages are locked in a constant battle and both are
perpetually changing their tactics to overcome each other. Bacteria use various strategies to …

High-dose methotrexate (MTX) chemotherapeutic applications confront drug specificity and
pharmacokinetic challenges, which can be overcome by utilizing targeted drug delivery …

Diabetic retinopathy (DR) is a vision-impairing complication of diabetes, damaging the
retinal microcirculatory system. Overexpression of VEGF (vascular endothelial growth factor) …

Introduction Despite the great therapeutic potential of gene therapy for treating critical
diseases, the clinical application is limited by lack of safe and effective gene delivery …

Purpose: Human telomerase reverse transcriptase (hTERT) plays a crucial role in
tumorigenesis and progression of cancers. Gene silencing of hTERT by short interfering …

Abstract Ischemia-reperfusion (I/R) injury is a leading cause of death worldwide. It arises
from blood reflowing after tissue hypoxia induced by ischemia that causes severe damages …

As research uncovers the underpinnings of cancer biology, new targeted therapies have
been developed. Many of these therapies are small molecules, such as kinase inhibitors …