[HTML][HTML] Cartilage and meniscal T2 relaxation time as non-invasive biomarker for knee osteoarthritis and cartilage repair procedures

T Baum, GB Joseph, DC Karampinos… - Osteoarthritis and …, 2013 - Elsevier
Objective The purpose of this work was to review the current literature on cartilage and
meniscal T2 relaxation time. Methods Electronic searches in PubMed were performed to …

[HTML][HTML] The relation between the biochemical composition of knee articular cartilage and quantitative MRI: a systematic review and meta-analysis

KS Emanuel, LJ Kellner, MJM Peters… - Osteoarthritis and …, 2022 - Elsevier
Objective Early and non-invasive detection of osteoarthritis (OA) is required to enable early
treatment and monitoring of interventions. Some of the earliest signs of OA are the change in …

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

G Du, T Liu, MM Lewis, L Kong, Y Wang… - Movement …, 2016 - Wiley Online Library
Background Parkinson's disease (PD) is marked pathologically by dopamine neuron loss
and iron overload in the substantia nigra pars compacta. Midbrain iron content is reported to …

Qualitative and quantitative ultrashort‐TE MRI of cortical bone

J Du, GM Bydder - NMR in biomedicine, 2013 - Wiley Online Library
Osteoporosis causes over 1.5 million fractures per year, costing about $15 billion annually in
the USA. Current guidelines utilize bone mineral density (BMD) to assess fracture risk; …

Early T2 changes predict onset of radiographic knee osteoarthritis: data from the osteoarthritis initiative

H Liebl, G Joseph, MC Nevitt, N Singh… - Annals of the rheumatic …, 2015 - Elsevier
Objective To evaluate whether T2 relaxation time measurements obtained at 3 T MRI predict
the onset of radiographic knee osteoarthritis (OA). Materials and methods We performed a …

Knee articular cartilage damage in osteoarthritis: analysis of MR image biomarker reproducibility in ACRIN-PA 4001 multicenter trial

TJ Mosher, Z Zhang, R Reddy, S Boudhar… - Radiology, 2011 - pubs.rsna.org
Purpose To prospectively determine the reproducibility of quantitative magnetic resonance
(MR) imaging biomarkers of the morphology and composition (spin lattice relaxation time in …

[HTML][HTML] Baseline mean and heterogeneity of MR cartilage T2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3 years …

GB Joseph, T Baum, H Alizai… - Osteoarthritis and …, 2012 - Elsevier
OBJECTIVE: The purpose of this study is to determine whether the mean and heterogeneity
of magnetic resonance (MR) knee cartilage T2 relaxation time measurements at baseline …

Predicting early symptomatic osteoarthritis in the human knee using machine learning classification of magnetic resonance images from the osteoarthritis initiative

BG Ashinsky, M Bouhrara, CE Coletta… - Journal of …, 2017 - Wiley Online Library
The purpose of this study is to evaluate the ability of a machine learning algorithm to classify
in vivo magnetic resonance images (MRI) of human articular cartilage for development of …

Ultrashort echo time imaging with bicomponent analysis

J Du, E Diaz, M Carl, W Bae, CB Chung… - Magnetic resonance …, 2012 - Wiley Online Library
Biological tissues frequently contain different water compartments, and these often have
distinct transverse relaxation times. Quantification of these may be problematic on clinical …

Texture analysis of cartilage T2 maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T2 compared to normal controls …

GB Joseph, T Baum, J Carballido-Gamio… - Arthritis research & …, 2011 - Springer
Introduction The goals of this study were (i) to compare the prevalence of focal knee
abnormalities, the mean cartilage T 2 relaxation time, and the spatial distribution of cartilage …