The cannabinoid receptor family currently includes twotypes: CB 1, characterized in
neuronal cells and brain, and CB 2, characterized in immune cells and tissues. CB 1 and CB …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

There are at least two types of cannabinoid receptor, CB1 and CB2, both G protein coupled.
CB1 receptors are expressed predominantly at nerve terminals and mediate inhibition of …

It is widely accepted that cannabinoids regulate GABA release by activation of cannabinoid
receptor type 1 (CB1). Results obtained from a variety of brain regions consistently indicate …

The kappa opioid receptor (KOR) is widely expressed in the CNS and can serve as a means
to modulate pain perception, stress responses, and affective reward states. Therefore, the …

Based on experimental evidence of the antinociceptive action of endocannabinoids and
their role in the modulation of trigeminovascular system activation, we hypothesized that the …

In this review I consider assays for G protein‐coupled receptor (GPCR) activity based on the
binding of labelled analogues of GTPγS ([35S] GTPγS or Eu‐GTPγS) to G proteins in tissues …

Cannabis is the most widely used illicit drug worldwide, though it is unclear whether its
regular use is associated with persistent alterations in brain morphology. This review …

Brain slices from 7-d-old Wistar rats were exposed to oxygen-glucose deprivation (OGD) for
30 min. OGD slices were incubated with vehicle or with the CB1/CB2 cannabinoid agonist …

The endocannabinoid system is involved in the regulation of many physiological effects in
the central and peripheral nervous system. Recent findings have demonstrated the …