The physical properties of ceramides in membranes

A Alonso, FM Goñi - Annual review of biophysics, 2018 - annualreviews.org
Ceramides are sphingolipids containing a sphingosine or a related base, to which a fatty
acid is linked through an amide bond. When incorporated into a lipid bilayer, ceramides …

How photoswitchable lipids affect the order and dynamics of lipid bilayers and embedded proteins

M Doroudgar, J Morstein, J Becker-Baldus… - Journal of the …, 2021 - ACS Publications
Altering the properties of phospholipid membranes by light is an attractive option for the
noninvasive manipulation of membrane proteins and cellular functions. Lipids with an …

Ceramide domains in health and disease: a biophysical perspective

AE Ventura, B Mestre, LC Silva - … in Health and Disease: Intertwined Roles …, 2019 - Springer
Ceramides are the central molecules in sphingolipid metabolism. In addition, they are
recognized as important modulators of cell function, playing key roles in several cellular …

Association of circulating ceramides with cardiac structure and function in the community: the Framingham Heart Study

CC Nwabuo, M Duncan, V Xanthakis… - Journal of the …, 2019 - Am Heart Assoc
Background A higher circulating plasma ceramide ratio (C16: 0/C24: 0) is associated with an
increased risk of heart failure, even after accounting for standard risk factors including lipid …

Early Life Exposure to C16-Ceramide Improves Learning and Short-Term Memory Behavior during Adulthood in Mice

CM Yeh, YY Sun, TY Chen, Y Hung… - ACS Chemical …, 2023 - ACS Publications
Ceramides, structural components of the cell, are known to play a range of roles in glucose
metabolism and apoptosis. C16-ceramide, an abundant molecular species of endogenous …

Differential pattern of phospholipid profile in the temporal cortex from E280A-familiar and sporadic Alzheimer's disease brains

JG Villamil-Ortiz, A Barrera-Ocampo… - Journal of …, 2018 - content.iospress.com
Lipids are considered important factors in the pathogenesis of Alzheimer's disease (AD). In
this study, we realized a comparative analysis of the phospholipid profile and phospholipid …

Long chain ceramides raise the main phase transition of monounsaturated phospholipids to physiological temperature

H Takahashi, T Hayakawa, A Makino, K Iwamoto… - Scientific Reports, 2022 - nature.com
Little is known about the molecular mechanisms of ceramide-mediated cellular signaling.
We examined the effects of palmitoyl ceramide (C16-ceramide) and stearoyl ceramide (C18 …

Mapping trasmembrane distribution of sphingomyelin

T Kobayashi - Emerging Topics in Life Sciences, 2023 - portlandpress.com
Our knowledge on the asymmetric distribution of sphingomyelin (SM) in the plasma
membrane is largely based on the biochemical analysis of erythrocytes using …

[HTML][HTML] Potential roles of exosomes in the initiation and metastatic progression of lung cancer

H Liang, L Zhang, J Rong - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Lung cancer (LC) incidence and mortality continue to increase annually worldwide. LC is
insidious and readily metastasizes and relapses. Except for its early diagnosis and surgical …

[HTML][HTML] The long chain base unsaturation has a stronger impact on 1-deoxy (methyl)-sphingolipids biophysical properties than the structure of its C1 functional group

TCB Santos, EM Saied, C Arenz, A Fedorov… - … et Biophysica Acta (BBA …, 2021 - Elsevier
deoxy-sphingolipids, also known as atypical sphingolipids, are directly implicated in the
development and progression of hereditary sensory and autonomic neuropathy type 1 and …