Key chemokines direct migration of immune cells in solid tumors
Immune cell infiltration into solid tumors, their movement within the tumor microenvironment
(TME), and interaction with other immune cells are controlled by their directed migration …
(TME), and interaction with other immune cells are controlled by their directed migration …
[HTML][HTML] Chemokines and chemokine receptors during COVID-19 infection
Chemokines are crucial inflammatory mediators needed during an immune response to
clear pathogens. However, their excessive release is the main cause of hyperinflammation …
clear pathogens. However, their excessive release is the main cause of hyperinflammation …
CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation–a target for novel cancer therapy
Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells,
and cause tissue extravasation. Given these properties, their role in anti-tumor immune …
and cause tissue extravasation. Given these properties, their role in anti-tumor immune …
Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals
F Gong, Y Dai, T Zheng, L Cheng… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Marked progress is achieved in understanding the physiopathology of
coronavirus disease 2019 (COVID-19), which caused a global pandemic. However, the …
coronavirus disease 2019 (COVID-19), which caused a global pandemic. However, the …
Learning single-cell perturbation responses using neural optimal transport
Understanding and predicting molecular responses in single cells upon chemical, genetic or
mechanical perturbations is a core question in biology. Obtaining single-cell measurements …
mechanical perturbations is a core question in biology. Obtaining single-cell measurements …
Overview of the mechanisms that may contribute to the non-redundant activities of interferon-inducible CXC chemokine receptor 3 ligands
M Metzemaekers, V Vanheule, R Janssens… - Frontiers in …, 2018 - frontiersin.org
The inflammatory chemokines CXCL9, CXCL10, and CXCL11 are predominantly induced
by interferon (IFN)-γ and share an exclusive chemokine receptor named CXC chemokine …
by interferon (IFN)-γ and share an exclusive chemokine receptor named CXC chemokine …
Role of inflammatory chemokines in hypertension
TP Mikolajczyk, P Szczepaniak, F Vidler… - Pharmacology & …, 2021 - Elsevier
Hypertension is associated with immune cells activation and their migration into the kidney,
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …
Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy
Loss-of-function mutations in genes encoding TET DNA dioxygenase occur frequently in
hematopoietic malignancy, but rarely in solid tumors, which instead commonly have reduced …
hematopoietic malignancy, but rarely in solid tumors, which instead commonly have reduced …
CXCR3 ligands: redundant, collaborative and antagonistic functions
JR Groom, AD Luster - Immunology and cell biology, 2011 - Wiley Online Library
CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation,
and preferentially remains highly expressed on type‐1 helper (Th1)‐type CD4+ T cells …
and preferentially remains highly expressed on type‐1 helper (Th1)‐type CD4+ T cells …
Antiviral actions of interferons
CE Samuel - Clinical microbiology reviews, 2001 - Am Soc Microbiol
Tremendous progress has been made in understanding the molecular basis of the antiviral
actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the …
actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the …