The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

Dopamine contributes to cognitive control through well-established effects in both the
striatum and cortex. Although earlier work suggests that dopamine affects cognitive control …

Deficits in cognition, reward processing, and motor function are clinical features relevant to
both aging and depression. Individuals with late-life depression often show impairment …

Recent work has highlighted neural mechanisms underlying cognitive effort-related
discounting of anticipated rewards. However, findings on whether effort exertion alters the …

Background Post-stroke fatigue (PSF) is a significant and highly prevalent symptom, whose
mechanisms are poorly understood. The third Stroke Recovery and Rehabilitation …

Individual differences in striatal dopamine synthesis capacity have been associated with
working memory capacity, trait impulsivity, and spontaneous eye-blink rate (sEBR), as …

Children with attention-deficit/hyperactivity disorder (ADHD) exhibit impairments in response
inhibition. These impairments are ameliorated by modulating dopamine (DA) via the …

Psychostimulants such as methylphenidate are widely used for their cognitive enhancing
effects, but there is large variability in the direction and extent of these effects. We tested the …

The majority of animal studies on methylphenidate (MP) use intraperitoneal (IP) injections,
subcutaneous (SC) injections, or the oral gavage route of administration. While all these …

Catecholamine-enhancing psychostimulants, such as methylphenidate have long been
argued to undermine creative thinking. However, prior evidence for this is weak or …