Role of Efflux Pumps on Antimicrobial Resistance in Pseudomonas aeruginosa

AB Lorusso, JA Carrara, CDN Barroso, FF Tuon… - International journal of …, 2022 - mdpi.com
Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in
parallel with new antibiotics, leading to a major global public health crisis over time …

Counteracting antibiotic resistance enzymes and efflux pumps

M Zheng, TJ Lupoli - Current opinion in microbiology, 2023 - Elsevier
Highlights•Adjuvants potentiate existing antibiotics or combat mechanisms of
resistance.•Probes enable the identification of enzymes that modify tuberculosis …

Outer Membrane Proteins and Efflux Pumps Mediated Multi-Drug Resistance in Salmonella: Rising Threat to Antimicrobial Therapy

SD Akshay, VK Deekshit, J Mohan Raj… - ACS Infectious …, 2023 - ACS Publications
Despite colossal achievements in antibiotic therapy in recent decades, drug-resistant
pathogens have remained a leading cause of death and economic loss globally. One such …

The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy

A Avakh, GD Grant, MJ Cheesman, T Kalkundri, S Hall - Antibiotics, 2023 - mdpi.com
Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …

Wearable adjunct ozone and antibiotic therapy system for treatment of Gram-negative dermal bacterial infection

A Roth, MK Maruthamuthu, S Nejati, A Krishnakumar… - Scientific Reports, 2022 - nature.com
The problematic combination of a rising prevalence of skin and soft tissue infections and the
growing rate of life-threatening antibiotic resistant infections presents an urgent, unmet need …

Halogenated antimicrobial agents to combat drug-resistant pathogens

OS Faleye, BR Boya, JH Lee, I Choi, J Lee - Pharmacological Reviews, 2024 - ASPET
Antimicrobial resistance presents us with a potential global crisis as it undermines the
abilities of conventional antibiotics to combat pathogenic microbes. The history of …

Efflux pump inhibitory potential of indole derivatives as an arsenal against norA over-expressing Staphylococcus aureus

N Chandal, R Tambat, R Kalia, G Kumar… - Microbiology …, 2023 - Am Soc Microbiol
NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to
fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also …

Boosting the Antibacterial Activity of Azithromycin on Multidrug-Resistant Escherichia coli by Efflux Pump Inhibition Coupled with Outer Membrane Permeabilization …

F Al-Marzooq, A Ghazawi, L Daoud, S Tariq - International journal of …, 2023 - mdpi.com
The global spread of multidrug-resistant (MDR) bacteria increases the demand for the
discovery of new antibiotics and adjuvants. Phenylalanine-arginine β-naphthylamide …

Nanocomposites against Pseudomonas aeruginosa biofilms: Recent advances, challenges, and future prospects

BA Omran, BS Tseng, KH Baek - Microbiological Research, 2024 - Elsevier
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that causes life-
threatening and persistent infections in immunocompromised patients. It is the culprit behind …

Biocompatibility and Safety Assessment of Combined Topical Ozone and Antibiotics for Treatment of Infected Wounds

A Roth, A Krishnakumar, RR McCain… - ACS Biomaterials …, 2023 - ACS Publications
Wound infections with antibiotic-resistant bacteria, particularly the Gram-negative strains,
pose a substantial health risk for patients with limited treatment options. Recently topical …