The interferons (IFNs) are cytokines with important antineoplastic and immune modulatory
effects. These cytokines have been conserved through evolution as important elements of …

Abstract Background Long non-coding RNAs (lncRNAs) have been identified as important
epigenetic regulators that play critical roles in human cancers. However, the regulatory …

Simple Summary The family of Schlafen (SLFN) genes are interferon-inducible genes that
control various cellular processes such as anti-viral responses, RNA regulatory processes …

Background: The drug 5-aminosalicylic acid (5-ASA) is the first-line therapy for the treatment
of patients with mild-to-moderate ulcerative colitis (UC). However, in some cases, 5-ASA …

Intestinal epithelial cells and the intestinal microbiota are in a mutualistic relationship that is
dependent on communication. This communication is multifaceted, but one aspect is …

Simple Summary IFNs are cytokines that play critical roles in the immune defense
mechanisms that prevent virus spread. They also exhibit regulatory effects on the immune …

Bowel resection accelerates enterocyte proliferation in the remaining gut with suboptimal
absorptive and digestive capacity because of a proliferation-associated decrease in …

Background The Schlafen (Slfn) family proteins are important for regulation of cell growth,
cell differentiation and cell cycle progression. We sought to distinguish Slfn family …

The colonic epithelium is continuously exposed to an array of biological and mechanical
stimuli as its luminal contents are guided over the epithelial surface through regulated …

Background: The intestinal lining renews itself in a programmed fashion that can be affected
by adaptation to surgical procedures such as gastric bypass. Methods: To assess adaptive …