A review on anticancer potential of bioactive heterocycle quinoline
The advent of Camptothecin added a new dimension in the field anticancer drug
development containing quinoline motif. Quinoline scaffold plays an important role in …
development containing quinoline motif. Quinoline scaffold plays an important role in …
Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives
Cancer is considered as one of the most serious health problems today. The discovery of
nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer …
nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer …
[HTML][HTML] Comprehensive review on current developments of quinoline-based anticancer agents
S Jain, V Chandra, PK Jain, K Pathak, D Pathak… - Arabian Journal of …, 2019 - Elsevier
Among heterocyclic compounds, quinoline scaffold has become an important construction
motif for the development of new drugs. Quinoline and its derivatives possess many types of …
motif for the development of new drugs. Quinoline and its derivatives possess many types of …
Quinoline as a privileged scaffold in cancer drug discovery
VR Solomon, H Lee - Current medicinal chemistry, 2011 - ingentaconnect.com
Quinoline (1-azanaphthalene) is a heterocyclic aromatic nitrogen compound characterized
by a double-ring structure that contains a benzene ring fused to pyridine at two adjacent …
by a double-ring structure that contains a benzene ring fused to pyridine at two adjacent …
Recent advances in research of natural and synthetic bioactive quinolines
PY Chung, ZX Bian, HY Pun, D Chan… - Future medicinal …, 2015 - Taylor & Francis
Many natural products that consist of quinoline core are found to be bioactive and the
versatility of quinoline and its derivatives have attracted great attention in the field of drug …
versatility of quinoline and its derivatives have attracted great attention in the field of drug …
Synthesis of 8-hydroxyquinoline derivatives as novel antitumor agents
SH Chan, CH Chui, SW Chan, SHL Kok… - ACS medicinal …, 2013 - ACS Publications
This letter describes the preparation of quinoline derivatives and their cytotoxic potentials
toward human carcinoma cell lines. Among the selected compounds, 8-hydroxy-2 …
toward human carcinoma cell lines. Among the selected compounds, 8-hydroxy-2 …
Multiple Topoisomerase I (TopoI), Topoisomerase II (TopoII) and Tyrosyl-DNA Phosphodiesterase (TDP) inhibitors in the development of anticancer drugs
E Baglini, S Salerno, E Barresi, M Robello… - European Journal of …, 2021 - Elsevier
DNA Topoisomerases (Topos) are ubiquitous nuclear enzymes involved in regulating the
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …
An overview of privileged scaffold: quinolines and isoquinolines in medicinal chemistry as anticancer agents
Y Mao, K Soni, C Sangani, Y Yao - Current Topics in Medicinal …, 2020 - ingentaconnect.com
Cancer is one of the most difficult diseases and causes of death for many decades. Many
pieces of research are continuously going on to get a solution for cancer. Quinoline and …
pieces of research are continuously going on to get a solution for cancer. Quinoline and …
Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates
B Marvania, PC Lee, R Chaniyara, H Dong… - Bioorganic & medicinal …, 2011 - Elsevier
A series of N-mustard-quinazoline conjugates was synthesized and subjected to antitumor
studies. The N-mustard pharmacophore was attached at the C-6 of the 4 …
studies. The N-mustard pharmacophore was attached at the C-6 of the 4 …
Diaryl urea: a privileged structure in anticancer agents
L Garuti, M Roberti, G Bottegoni… - Current medicinal …, 2016 - ingentaconnect.com
The diaryl urea is an important fragment/pharmacophore in constructing anticancer
molecules due to its near-perfect binding with certain acceptors. The urea NH moiety is a …
molecules due to its near-perfect binding with certain acceptors. The urea NH moiety is a …