The advent of Camptothecin added a new dimension in the field anticancer drug
development containing quinoline motif. Quinoline scaffold plays an important role in …

Cancer is considered as one of the most serious health problems today. The discovery of
nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer …

Among heterocyclic compounds, quinoline scaffold has become an important construction
motif for the development of new drugs. Quinoline and its derivatives possess many types of …

Quinoline (1-azanaphthalene) is a heterocyclic aromatic nitrogen compound characterized
by a double-ring structure that contains a benzene ring fused to pyridine at two adjacent …

Many natural products that consist of quinoline core are found to be bioactive and the
versatility of quinoline and its derivatives have attracted great attention in the field of drug …

This letter describes the preparation of quinoline derivatives and their cytotoxic potentials
toward human carcinoma cell lines. Among the selected compounds, 8-hydroxy-2 …

DNA Topoisomerases (Topos) are ubiquitous nuclear enzymes involved in regulating the
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …

Cancer is one of the most difficult diseases and causes of death for many decades. Many
pieces of research are continuously going on to get a solution for cancer. Quinoline and …

A series of N-mustard-quinazoline conjugates was synthesized and subjected to antitumor
studies. The N-mustard pharmacophore was attached at the C-6 of the 4 …

The diaryl urea is an important fragment/pharmacophore in constructing anticancer
molecules due to its near-perfect binding with certain acceptors. The urea NH moiety is a …