Pathogenesis of acute respiratory distress syndrome

LA Huppert, MA Matthay… - Seminars in respiratory and …, 2019 - thieme-connect.com
Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure
caused by noncardiogenic pulmonary edema. Despite five decades of basic and clinical …

Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications

S Rani, AE Ryan, MD Griffin, T Ritter - Molecular Therapy, 2015 - cell.com
Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …

Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial

MA Matthay, CS Calfee, H Zhuo… - The Lancet …, 2019 - thelancet.com
Background Treatment with bone-marrow-derived mesenchymal stromal cells (MSCs) has
shown benefits in preclinical models of acute respiratory distress syndrome (ARDS). Safety …

Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series

SMR Hashemian, R Aliannejad, M Zarrabi… - Stem cell research & …, 2021 - Springer
Background Acute respiratory distress syndrome (ARDS) is a fatal complication of
coronavirus disease 2019 (COVID-19). There are a few reports of allogeneic human …

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

DG Phinney, M Di Giuseppe, J Njah, E Sala… - Nature …, 2015 - nature.com
Mesenchymal stem cells (MSCs) and macrophages are fundamental components of the
stem cell niche and function coordinately to regulate haematopoietic stem cell self-renewal …

Acute lung injury

NT Mowery, WTH Terzian, AC Nelson - Current problems in surgery, 2020 - Elsevier
The clinical description that defines acute lung injury (ALI) has been around for more than
50 years. The clinical picture has carried many different definitions, but what was known as …

Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial

JG Wilson, KD Liu, H Zhuo, L Caballero… - The Lancet …, 2015 - thelancet.com
Background No effective pharmacotherapy for acute respiratory distress syndrome (ARDS)
exists, and mortality remains high. Preclinical studies support the efficacy of mesenchymal …

The acute respiratory distress syndrome

MA Matthay, LB Ware… - The Journal of clinical …, 2012 - Am Soc Clin Investig
The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory
failure that is often associated with multiple organ failure. Several clinical disorders can …

Mesenchymal stem cells: a new trend for cell therapy

X Wei, X Yang, Z Han, F Qu, L Shao… - Acta Pharmacologica …, 2013 - nature.com
Mesenchymal stem cells (MSCs), the major stem cells for cell therapy, have been used in
the clinic for approximately 10 years. From animal models to clinical trials, MSCs have …

Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy

S Kourembanas - Annual review of physiology, 2015 - annualreviews.org
Mesenchymal stem cells (MSCs), whose mechanism of action is predominantly paracrine,
are being widely tested for the treatment of a variety of human diseases. No one factor has …