New iron metabolic pathways and chelation targeting strategies affecting the treatment of all types and stages of cancer

GJ Kontoghiorghes - International Journal of Molecular Sciences, 2022 - mdpi.com
There is new and increasing evidence from in vitro, in vivo and clinical studies implicating
the pivotal role of iron and associated metabolic pathways in the initiation, progression and …

Bispecific antibody-based immune-cell engagers and their emerging therapeutic targets in cancer immunotherapy

HG Shin, HR Yang, A Yoon, S Lee - International Journal of Molecular …, 2022 - mdpi.com
Cancer is the second leading cause of death worldwide after cardiovascular diseases.
Harnessing the power of immune cells is a promising strategy to improve the antitumor effect …

[HTML][HTML] A chromatographic network for the purification of detergent-solubilized six-transmembrane epithelial antigen of the prostate 1 from Komagataella pastoris mini …

J Barroca-Ferreira, AM Gonçalves, MFA Santos… - … of Chromatography A, 2022 - Elsevier
Abstract The Six-Transmembrane Epithelial Antigen of the Prostate 1 (STEAP1) is an
integral membrane protein involved in cellular communications, in the stimulation of cell …

Effect and mechanism of Mn2+ on urease activity during anaerobic biological treatment of landfill leachate

H Liu, J Huang, H Zhang, S Xi, T Luo… - Environmental Science and …, 2024 - Springer
As a crucial hydrolytic enzyme, urease plays a vital role in anaerobic biological treatment. It
is well-known that manganese ions are abundant in landfill leachate, but their concentration …

Screening of buffers and additives for protein stabilization by thermal shift assay: a practical approach

FSS Engrola, J Paquete-Ferreira… - Advanced Methods in …, 2023 - Springer
Thermal shift assay (TSA), also commonly designed by differential scanning fluorimetry
(DSF) or ThermoFluor, is a technique relatively easy to implement and perform, useful in a …

Specific Six-Transmembrane Epithelial Antigen of the Prostate 1 Capture with Gellan Gum Microspheres: Design, Optimization and Integration

J Batista-Silva, D Gomes, J Barroca-Ferreira… - International Journal of …, 2023 - mdpi.com
This work demonstrates the potential of calcium-and nickel-crosslinked Gellan Gum (GG)
microspheres to capture the Six-Transmembrane Epithelial Antigen of the Prostate 1 …

Unveiling Biopathways from the Biosynthesis Towards the Purification of STEAP1 Protein new Insights on Stability, Structure, and Function

JDB Ferreira - 2023 - search.proquest.com
Abstract Em 2020, mais de 1.4 milhões de novos casos de cancro da próstata (CPa) foram
diagnosticados em homens em todo o mundo originando aproximadamente 375,000 …

Isolation of the Six-Transmembrane Epithelial Antigen of the Prostate 1 (STEAP1) Using Gellan Gum Microspheres

JPB da Silva - 2022 - search.proquest.com
Prostate cancer is one of the most frequent cancers diagnosed in males, predicted to
become the most prevalent malignancy in upcoming years. Current therapies have limited …

[引用][C] Isolation of the Six-Transmembrane Epithelial Antigen of the Prostate 1 (STEAP1) using Gellan Gum Microspheres

JPB Silva - 2022