Purpose To review the impact of collaborative studies on advances in the biology and
treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. Methods A …

The antileukemic mechanisms of 6-mercaptopurine (6MP) and methotrexate (MTX)
maintenance therapy are poorly understood, but the benefits of several years of …

Contemporary chemotherapy for childhood acute lymphoblastic leukemia (ALL) is risk-
adapted based on clinical features, leukemia genomics and minimal residual disease …

Precision oncology has made significant advances, mainly by targeting actionable mutations
in cancer driver genes. Aiming to expand treatment opportunities, recent studies have begun …

Interleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether
acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger …

Survivors of childhood cancer frequently experience cancer-related cognitive dysfunction,
commonly months to years after treatment for pediatric brain tumors, acute lymphoblastic …

As the cure rates for haematological malignancies have improved, the exploration of the
balance between efficacy and side effects has become a major research target. The …

Cancer-related metabolism has recently emerged as one of the “hallmarks of cancer”. It has
several important features, including altered metabolism of glucose and glutamine …

To determine whether gene expression profiling could improve outcome prediction in
children with acute lymphoblastic leukemia (ALL) at high risk for relapse, we profiled …

Context Pediatric acute lymphoblastic leukemia (ALL) is the prototype for a drug-responsive
malignancy. Although cure rates exceed 80%, considerable unexplained interindividual …