Growth hormone (GH) has long been known to stimulate linear growth and regulate
metabolism. The cellular mechanism by which GH elicits these effects has only recently …

Events relayed via the single transmembrane receptor for erythropoietin (Epo) are essential
for the development of committed erythroid progenitor cells beyond the colony-forming unit …

Protein kinase C (PKC) was first described as a calcium-activated, phospholipid-dependent
serine/threonine protein kinase 22 years ago, and it has since been studied extensively as a …

The cytoplasmic domain of the erythropoietin receptor (EpoR) contains a membrane-distal
region that is dispensable for mitogenesis but is required for the recruitment and tyrosine …

Abstract The phosphatidylinositol 3-kinase (PI3K) signaling pathway is important for the
regulation of a number of cellular responses. Serine/threonine kinase Akt (protein kinase B; …

Regulation of cellular metabolism by the citric acid cycle occurs in the mitochondria.
However, the citric acid cycle intermediate succinate was shown recently to be a ligand for …

Hematopoiesis is regulated through the binding of cytokines to receptors of the cytokine
receptor superfamily. Although lacking catalytic domains, members of the cytokine receptor …

The hematopoietic cytokine erythropoietin (Epo) prevents neuronal death during ischemic
events in the brain and in neurodegenerative diseases, presumably through its antiapoptotic …

Red blood cells arise continuously from pluripotent stem cells which mature and become
functionally specialized upon commitment to the erythroid lineage. In mammals, the key …

In order to ascertain whether erythropoietin plays a role in early and late repair processes
following ischaemic skin flap injury, a dorsal, caudally based skin flap was created in rats …