Lessons learned from clinical trials using antimicrobial peptides (AMPs)

GS Dijksteel, MMW Ulrich, E Middelkoop… - Frontiers in …, 2021 - frontiersin.org
Antimicrobial peptides (AMPs) or host defense peptides protect the host against various
pathogens such as yeast, fungi, viruses and bacteria. AMPs also display immunomodulatory …

The Role of Macrophages in Staphylococcus aureus Infection

GR Pidwill, JF Gibson, J Cole, SA Renshaw… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is a member of the human commensal microflora that exists,
apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it …

Methicillin-resistant Staphylococcus aureus (MRSA): antibiotic-resistance and the biofilm phenotype

KM Craft, JM Nguyen, LJ Berg, SD Townsend - MedChemComm, 2019 - pubs.rsc.org
Staphylococcus aureus (S. aureus) is an asymptomatic colonizer of 30% of all human
beings. While generally benign, antibiotic resistance contributes to the success of S. aureus …

The Continuing Threat of Methicillin-Resistant Staphylococcus aureus

M Gajdács - Antibiotics, 2019 - mdpi.com
Staphylococcus aureus has been an exceptionally successful pathogen, which is still
relevant in modern age-medicine due to its adaptability and tenacity. This bacterium may be …

Staphylococcus aureus pathogenesis in diverse host environments

D Balasubramanian, L Harper, B Shopsin… - Pathogens and …, 2017 - academic.oup.com
Staphylococcus aureus is an eminent human pathogen that can colonize the human host
and cause severe life-threatening illnesses. This bacterium can reside in and infect a wide …

Coagulase-negative staphylococci pathogenomics

X Argemi, Y Hansmann, K Prola, G Prévost - International journal of …, 2019 - mdpi.com
Coagulase-negative Staphylococci (CoNS) are skin commensal bacteria. Besides their role
in maintaining homeostasis, CoNS have emerged as major pathogens in nosocomial …

Vaccines against antimicrobial resistance

R Rosini, S Nicchi, M Pizza, R Rappuoli - Frontiers in immunology, 2020 - frontiersin.org
In the last century, life expectancy has increased considerably, thanks to the introduction of
antibiotics, hygiene and vaccines that have contributed to the cure and prevention of many …

Immunoinformatics analysis and in silico designing of a novel multi-epitope peptide vaccine against Staphylococcus aureus

N Hajighahramani, N Nezafat, M Eslami… - Infection, Genetics and …, 2017 - Elsevier
Staphylococcus aureus is a pathogen that causes a variety of infections in humans.
Methicillin-resistant S. aureus, which is an antibiotic-resistant form, is responsible for …

Staphylococcus aureus Manipulates Innate Immunity through Own and Host-Expressed Proteases

G Pietrocola, G Nobile, S Rindi… - Frontiers in cellular and …, 2017 - frontiersin.org
Neutrophils, complement system and skin collectively represent the main elements of the
innate immune system, the first line of defense of the host against many common …

The diverse impacts of phage morons on bacterial fitness and virulence

VL Taylor, AD Fitzpatrick, Z Islam, KL Maxwell - Advances in virus research, 2019 - Elsevier
The viruses that infect bacteria, known as phages, are the most abundant biological entity on
earth. They play critical roles in controlling bacterial populations through phage-mediated …