Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied
female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated …

Abstract The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs)
enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that …

Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …

Proteases have long been associated with cancer progression because of their ability to
degrade extracellular matrices, which facilitates invasion and metastasis. However, recent …

Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We
obtained 221 transcriptomes from bovids and cervids and sequenced three genomes …

ADAMTSs (A disintegrin and metalloprotease domains with thrombospondins motifs) are
complex extracellular proteases that have been related to both oncogenic and tumor …

Background Acquisition of the intestinal microbiota in early life corresponds with the
development of the mucosal immune system. Recent work on caesarean-delivered infants …

Matrix metalloproteinases (MMPs) have long been linked to cancer progression owing to
their ability to breakdown tissue barriers for metastatic spread. Accordingly, multiple studies …

Normal pregnancy (NP) involves intricate processes starting with egg fertilization,
proceeding to embryo implantation, placentation and gestation, and culminating in …

As one of major epigenetic changes to inactivate tumor suppressor genes in human
carcinogenesis, promoter hypermethylation was proposed as a marker to define novel tumor …