Experimental and clinical data strongly support a role for the eosinophil in the pathogenesis
of asthma, allergic and parasitic diseases, and hypereosinophilic syndromes, in addition to …

Eosinophil granulocytes reside in respiratory mucosa including lungs, in the gastro-intestinal
tract, and in lymphocyte associated organs, the thymus, lymph nodes and the spleen. In …

Mast cells (MCs) act as primary effectors in inflammatory and allergic reactions by releasing
intracellularly-stored inflammatory mediators in diseases. The two major pathways for MC …

Human ribonucleases (RNases) are members of a large superfamily of rapidly evolving
homologous proteins. Upon completion of the human genome, eight catalytically active …

Onconase®(ONC) is an amphibian member of the bovine pancreatic ribonuclease (RNase
A) superfamily that exhibits innate antitumoral activity. ONC has been granted both orphan …

The review starts with a general outlook of the main mechanisms of action of antimicrobial
proteins and peptides, with the final aim of understanding the biological function of …

Human blood monocytes can be broadly divided into two distinct subsets: CD14+ CD16−
and CD14+/lowCD16+ subsets. Perturbation in their proportions in the blood has been …

Background The objective of this work was to assess the efficacy of serum eosinophil
cationic protein (ECP) concentration in predicting early postoperative recurrence in patients …

Ribonucleases (RNases) are a large number of enzymes gathered into different bacterial or
eukaryotic superfamilies. Bovine pancreatic RNase A, bovine seminal BS-RNase, human …

Eosinophils have been associated with the pathophysiology of various allergic diseases and
asthma. Eosinophils secrete a number of granule proteins that have been identified as …