Introduction Irisin is a myokine/adipokine induced by the exercise in mice and humans,
which is proposed to induce “browning” of white adipose tissue, its primary target, thus …

Irisin is a myokine derived from the cleavage of fibronectin type III domain-containing 5. Irisin
regulates mitochondrial energy, glucose metabolism, fatty acid oxidation, and fat browning …

Oxidative stress and cardiomyocyte apoptosis play critical roles in doxorubicin (DOX)-
induced cardiotoxicity. Previous studies indicated that fibronectin type III domain-containing …

In the last few years, the muscular system has gained attention due to the discovery of the
muscle-secretome and its high potency for retaining or regaining health. These cytokines …

Irisin is a hormone-like molecule mainly released by skeletal muscles in response to
exercise. Irisin induces browning of the white adipose tissue and has been shown to …

Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease
from a membrane‐spanning protein, FNDC5 (fibronectin type III domain‐containing protein …

Heart failure (HF) is a global medical problem that characterizes poor prognosis and high
economic burden for the health system and family of the HF patients. Although modern …

Chronic kidney disease–mineral and bone disorder (CKD–MBD) is a systemic disorder that
affects multiple organs and systems and increases the risk of morbidity and mortality in …

Exercise not only produces beneficial effects on muscle itself via various molecular
pathways, but also mediates the interaction between muscles and other organs in an …

Non-coding RNAs (ncRNAs) encompass a family of ubiquitous RNA molecules that lack
protein-coding potential and have tissue-specific expression. A significant body of evidence …