Over the past decade, many studies have indicated that adolescence is a critical period of
brain development and maturation. The refinement and maturation of the central nervous …

Rho GTPases family are considered to be molecular switches that regulate various cellular
processes, including cytoskeleton remodeling, cell polarity, synaptic development and …

Growing evidence suggests that the gut microbiome (GM) plays a critical role in health and
disease. However, the contribution of GM to psychiatric disorders, especially anxiety …

Patch-clamp and multi-electrode array electrophysiology techniques are used to measure
dynamic functional properties of neurons. Whole-cell and cell-attached patch-clamp …

Background Stressful episodes and high alcohol consumption during adolescence are
considered major risk factors for the development of psychiatric disorders in adulthood …

It is essential to identify the neuronal mechanisms of Alzheimer's Disease (AD)-associated
neuropsychiatric symptoms, eg, apathy, before improving the life quality of AD patients …

Background Adolescence and early-adulthood are vulnerable developmental periods
during which binge drinking can have long-lasting effects on brain function. However, little is …

Chronic intermittent ethanol and withdrawal (CIE/WD) produces alcohol dependence,
facilitates anxiety-like behavior, and increases post-CIE alcohol intake. The basolateral …

Rationale: Neuroadaptations in the medial prefrontal cortex (mPFC) and Nucleus
Accumbens (NAc) play a role in the disruption of control-reward circuits in opioid addiction …

The transition from occasional to escalated psychostimulant use is accelerated by prior drug
exposure. These behavioral observations may be related to long-lasting transcriptional …